atypical cystic lobule

atypical cystic lobule (breast)

A type of columnar cell lesion of the terminal duct lobular unit of the breast, which is characterised by mounds, tufts and short micropapillations of columnar cells greater than two cells in thickness; it is considered a precursor of low-grade ductal carcinoma in situ (DCIS).
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Meanwhile, several investigators have found association of tubular carcinoma, as well as lobular intraepithelial neoplasia (LIN), with clinging pattern in breast biopsies (7-10) and have published this distinct morphologic change under a variety of terms such as atypical cystic lobules, (11,12) atypical lobules type A, (13) atypical cystic duct, (14,15) columnar cell change with atypia, (16-18) columnar alteration with prominent apical snouts and secretion, (19-21) columnar cell hyperplasia (with or without atypia), (22-25) small ectatic ducts lined by atypical cells with apocrine snouts, (26) ductal intraepithelial neoplasia (DIN), flat type, (2,6,27) flat epithelial atypia, (16,28-30) and enlarged lobular units with columnar alteration.
These include atypical cystic lobules, atypical lobules type A, clinging carcinoma, clinging carcinoma in situ, columnar alteration of lobules, columnar cell change with atypia, atypical columnar change, columnar alteration with prominent apical snouts and secretion, columnar cell hyperplasia (with or without atypia), small ectatic ducts lined by atypical cells with apocrine snouts, cancerization of small ecstatic ducts of the breast by ductal carcinoma in situ cells with apocrine snouts, and enlarged lobular units with columnar alteration.
Atypical cystic lobules of the breast: an early stage of low-grade ductal carcinoma in situ.
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