atypical carcinoid

atypical carcinoid

An intermediate form of neuroendocrine tumour between low-grade malignant (typical carcinoid) and high-grade small cell carcinoma.

Prognosis
Nodal metastases in 70% (vs. 5% for carcinoids); 5-year survival is 60%.

atypical carcinoid

An intermediate form of neuroendocrine tumor between low-grade malignant–typical carcinoid and high-grade small cell carcinoma. See Carcinoid, Small cell carcinoma.
References in periodicals archive ?
Typical Carcinoid (TC) comprise 1-2% and Atypical Carcinoid (AC) comprise 0.1-0.2% of all pulmonary tumors, whereas small cell lung carcinoma (SCLC) and Large Cell Neuroendocrine Carcinoma (LCNECs) make up 20% and 1.6-3%, respectively
Hence, diagnosis of thymic atypical carcinoid was considered with the positivity for synaptophysin and chromogranin along with CK7 positivity (Figure 5).
The recurrence rate for typical carcinoid is lower (3.6%) than that of atypical carcinoid (33.3%) [5].
CAPNCI uses four general categories for neuroendocrine tumors of the uterine cervix, typical (classical) carcinoid tumor, atypical carcinoid tumor, large cell neuroendocrine carcinoma, and small (oat) cell carcinoma [1].
Cueto et al., "Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence," Thorax, vol.
Depending on the location of the NET (foregut, hindgut, and pulmonary) other hormones can predominate in systemic circulation resulting in an atypical carcinoid syndrome with variant clinical symptoms [22].
WHO (2005) classified neuroendocrine tumor (NET) of the larynx into 4 types: (1) typical carcinoid, (2) atypical carcinoid (AC), (3) small cell carcinoma, neuroendocrine type, and (4) combined small cell carcinoma, neuroendocrine type, with nonsmall cell carcinoma [1].
Neuroendocrine neoplasms of the larynx encompass five separate tumors: paraganglioma, typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma.
Atypical carcinoidis based upon four elements: a morphological base, number of mitoses less than 2 per 10HPFs, absence of necrosis and dimension less than 0.5 cm; while an atypical carcinoid shows carcinoid morphology with number of mitoses greater than 2 and less than 10 per 10 HPFs and areas of coagulative necrosis.3 The histopathology report of our patient showed approximately 1 mitosis/HPF which favoured a diagnosis of typical carcinoid.
Atypical carcinoid (2-10 mitoses/10 HPF, with necrosis) has an intermediate behavior [6].
We present the case of an atypical carcinoid tumor of lung origin metastasizing to a known pituitary adenoma.

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