(10) Apocrine proliferations include benign lesions, such as apocrine metaplasia, apocrine adenosis, and apocrine-rich papillomas, in addition to atypical and malignant lesions, including atypical apocrine adenosis, atypical apocrine hyperplasia, apocrine DCIS, and invasive carcinoma with apocrine features.
Atypical apocrine adenosis of the breast: a clinicopathologic study of 37 patients with 8.7-year follow-up.
Atypical apocrine adenosis diagnosed on breast core biopsy: implications for management.
Among atypical and malignant lesions with apocrine features are atypical apocrine adenosis (AAA), apocrine ductal carcinoma in situ (DCIS), and invasive carcinoma with apocrine features.
It has been reported that significant cytologic atypia in apocrine cells is characterized by a 3-fold nuclear enlargement, prominent/ multiple pleomorphic nucleoli, and hyperchromasia.12 The term atypical apocrine adenosis refers to apocrine atypia within sclerosing adenosis (Figure 4).
Atypical apocrine adenosis of the breast; a clinicopathological study of 37 patients with 8.7 year follow up.
Kleer, MD, report the morphologic and diagnostic features of atypical apocrine adenosis
, an uncommon yet very challenging breast lesion.
(3) It is well recognized that the cytologic alterations can be misdiagnosed as apocrine ductal carcinoma in situ (apocrine DCIS) if pathologists do not apply diagnostic criteria for atypical apocrine adenosis (AAA).
The objective of this study was to determine the breast cancer risk in a retrospective series of patients diagnosed with atypical apocrine adenosis in otherwise benign breast excisional biopsies.
This case, an example of apocrine DCIS presenting as "atypical apocrine adenosis" in a core biopsy, will be used to discuss and illustrate some unresolved controversies involving apocrine metaplasia and its relationship to breast carcinoma.
There is some evidence that atypical apocrine adenosis lesions are associated with increased breast cancer risk.
Microscopic examination of the left breast biopsy revealed benign proliferative changes, cysts, and multiple foci of atypical apocrine adenosis