atypical antipsychotic

Also found in: Dictionary, Thesaurus, Wikipedia.
Related to atypical antipsychotic: Pregabalin, risperidone, Atypical Antipsychotic Drugs

atypical antipsychotic

A dibenzepine-type antipsychotic which differs from conventional antipsychotics in its paucity of extrapyramidal effects (tremor, muscle stiffness and restlessness).
Adverse effects
Insomnia, anxiety, agitation, sedation, dizziness, rhinitis, orthostatic hypotension, tachycardia, weight gain, menstrual disturbances, seizures; rarely, severe granulocytopaenia or agranulocytosis; should not be used in patients with liver, brain or circulatory defects.
Clozapine (Clozaril), ziprasidone (Geodon), loxapine (Loxitane), olanzapine (Zyprexa), resperidone (Risperdal), quetiapine (Seroquel).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


(ant?i-si?kot'ik) [ anti- + psychotic]
1. Preventing or treating psychosis, e.g., schizophrenia.
2. A medication to treat psychosis.

atypical antipsychotic

Second-generation antipsychotic.

first-generation antipsychotic

A neuroleptic drug. They treat psychotic disorders and other psychiatric diseases. Side effects include extrapyramidal (Parkinsonian) reactions. Synonym: conventional antipsychotic See: neuroleptic (1)

conventional antipsychotic

First-generation antipsychotic.

second-generation antipsychotic

An antipsychotic drug that causes increased appetite, weight gain, and adverse effects on lipids. They differ from first-generation antipsychotics in that they are less likely to cause extrapyramidal side effects or tardive dyskinesia.
Synonym: atypical antipsychotic
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
With the launch of LATUDA, a new treatment option for patients with schizophrenia in China, along with another atypical antipsychotic LONASEN already launched in February 2018, Sumitomo Dainippon Pharma expects to make a greater contribution to the treatment of patients with schizophrenia in China.
Atypical antipsychotics are much better than the conventional antipsychotic and do not cause extra pyramidal symptoms.
For example, researchers led by Frank Habermann, PhD, prospectively evaluated three cohorts who were followed in a psychiatry consultation in Freiburg, Germany: 453 women who received atypical antipsychotics in the first trimester of pregnancy (group A); 238 women who received typical antipsychotics in the first trimester of pregnancy (group B); and 1,104 women who had no records of treatment with medications associated with harmful fetal effects (group C).
Perospirone and Tiospirone are atypical antipsychotic drugs which are azapirone derivatives (Kikuyama et al., 2006; Yevich et al., 1986).
Until relatively recently, data on the reproductive safety of second-generation atypical antipsychotics have been relatively sparse, with the small number of prospective studies yielding a small total number of patients.
(2004) carried out a review study on NMS associated with atypical antipsychotic drugs.
Conclusion: Because of the widespread use of atypical antipsychotics, we observed atypical antipsychotic exposures more than typical antipsychotic exposures.
Paliperidone was the atypical antipsychotic with the longer mean QT and QTc values (390.5 [+ or -] 29.8; 411.4 [+ or -] 20.3).
Olanzapine, a thienobenzodiazepine, is an atypical antipsychotic drug with a high affinity for the serotoninergic receptors 5-HT2 and 5-HT6, and a low affinity for 5-HT3 receptors in vitro.
Dopamine depletion of the prefrontal cortex induces dendritic spine loss: reversal by atypical antipsychotic drug treatment.
Of these, 48,087 (36%) had one or more nonpsychotic diagnoses, and 9.6% received at least one prescription for an atypical antipsychotic drug between 2010 and 2012.
Zito and her colleagues collected information about prior authorization requirements for atypical antipsychotic prescribing for all 50 states and the District of Columbia.