atypical Spitz nevus

atypical Spitz nevus

A Spitz-nevus-like tumour of the skin with one or more atypical features, for which prudent pathologists would recommend close followup.

Spitz nevus features—classical vs atypical
• Size—< 10 mm vs > 10 mm.
• Symmetry—Symmetrical vs Asymmetrical.
• Lateral borders—Sharply demarcated vs Poorly demarcated.
• Deep border—Rounded, pushing vs Infiltrative.
• Cellularity—Variable vs Clustered cells in dermis.
• Irregular nesting—Rare vs Common.
• Deep extension—Rare vs Common.
• Expansile nodule—Rare vs Common.
• Deep mitoses—Rare vs Common.
• Ulceration—Rare vs Variable.
• Maturation/zonation—Common vs Rare.
• Kamino bodies—Common vs Rare.
References in periodicals archive ?
2) On occasion, Spitz nevi may demonstrate greater degrees of atypia, characterized by higher-grade cytologic atypia, increased pagetoid scatter, and/or architectural overlap with dysplastic nevus, such that the terms dysplastic Spitz nevus or atypical Spitz nevus are used.
As discussed above, PEM is a prototypical example of melanocytoma and atypical Spitz nevus and, perhaps, atypical deep-penetrating tumors are additional candidates.
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