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a clay mineral that contains aluminum silicate and is the main ingredient of fuller's earth; activated attapulgite is a heat-treated form that is administered orally in the treatment of diarrhea.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Children's Kaopectate(trade name),
Fowler’s Anti-Diarrhea Tablets(trade name),
Fowler's attapulgite oral suspension(trade name),
Kaopectate Extra Strength(trade name)
Pregnancy Category: B
Adjunct in the symptomatic management of mild to moderate acute diarrhea.
Appears to act by adsorbing bacteria and toxins and decreasing loss of water.
Decreased number and water content of stools.
Absorption: Action is local. Attapulgite is not absorbed.
Metabolism and Excretion: Unknown.
Time/action profile (antidiarrheal effect)
Contraindicated in: Hypersensitivity; Severe dehydration; Diarrhea that may be caused by parasites; Dysentery.
Use Cautiously in: Pediatric / Geriatric: Children <3 yr or geriatric patients have increased risk of dehydration.
Adverse Reactions/Side Effects
Drug-Drug interactionMay decrease the gastrointestinal absorption of concurrently administered oral medications (administer 2–3 hr before or 2–4 hr after attapulgite).
Oral (Adults) 1.2–3 g after each loose stool (not to exceed 9 g/24 hr).
Oral (Children 6–12 yr) 600–1500 mg after each loose stool (not to exceed 4.5 g/24 hr).
Oral (Children 3–6 yr) 300–750 mg after each loose stool (not to exceed 2.25 g/24 hr).
Oral suspension: 600 mg/15 mLOTC, 750 mg/5 mLOTC, 900 mg/15 mLOTC
Tablets: 630 mgOTC
- Assess the frequency and consistency of stools and bowel sounds before and throughout course of therapy.
- Assess fluid and electrolyte balance and skin turgor for dehydration.
Potential Nursing DiagnosesDiarrhea (Indications)
Constipation (Side Effects)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)
- Administer after each loose bowel movement until diarrhea is controlled.
- Do not administer other medications within 2–3 hr before or after attapulgite administration.
- Oral: Shake suspension well before administration.
- Instruct patient to notify health care professional if diarrhea persists longer than 48 hr or if fever or abdominal pain develops.
- Advise patient or parent not to use attapulgite and to notify health care professional if stool contains blood or mucus or is accompanied by fever.
- Decrease in frequency of loose stools.
- Return to soft, formed stools.
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