atrophic gastritis


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Related to atrophic gastritis: pernicious anemia

gastritis

 [gas-tri´tis]
inflammation of the lining of the stomach. Gastritis is one of the most common stomach disorders, and occurs in acute, chronic, and toxic forms.
acute gastritis severe gastritis that may be caused by intake of aspirin or other nonsteroidal antiinflammatory drugs, food poisoning, overeating, excessive intake of alcoholic beverages, or bacterial or viral infection; it is often accompanied by enteritis. The outstanding symptom is abdominal pain, and there is also a feeling of distention, with loss of appetite and nausea. There may be a slight fever and vomiting. The substance causing the irritation can often be identified, in which case it should be avoided. Treatment may include the use of antacids. A bland diet of liquids and easily digested food should be followed for 2 or 3 days. Simply prepared solid foods in small quantities can then be added.
atrophic gastritis chronic gastritis with atrophy of the mucous membranes and glands.
chronic gastritis gastritis that occurs repeatedly or continues over a period of time. Although pain, especially after eating, and symptoms associated with indigestion may occur in chronic gastritis, most patients are asymptomatic; however, the condition may lead to hemorrhage and ulcer formation. Among its possible causes are Helicobacter pylori, vitamin deficiencies, abnormalities of the gastric juice, ulcers, hiatus hernia, excessive use of alcohol, or a combination of any of these.

Chronic gastritis is treated with a bland diet; food should be taken frequently and in small amounts. Antacids or anticholinergics may also be used in moderation to minimize stomach acidity. If bleeding is a problem that cannot be controlled by conservative measures, partial gastrectomy, pyloroplasty, vagotomy, or total gastrectomy may be indicated.
giant hypertrophic gastritis Ménétrier's disease.
toxic gastritis gastritis resulting from ingestion of a corrosive substance such as a strong acid or poison. There is an acute burning sensation and cramping stomach pain, accompanied by diarrhea and vomiting; the vomit may be bloody. The victim may collapse. This condition is an emergency and immediate measures must be taken to prevent serious damage to the tissues of the stomach. First aid measures are begun at once to flush out and neutralize the poison.

a·troph·ic gas·tri·tis

chronic gastritis with atrophy of the mucous membrane and destruction of the peptic glands, sometimes associated with pernicious anemia or gastric carcinoma; also applied to gastric atrophy without inflammatory changes.

atrophic gastritis

A type of chronic gastritis, which is characterised by inflammatory destruction of specialised parietal and chief cell zones, leading to atrophy, mucus neck cell metaplasia, intestinal metaplasia and pancreatic acinar metaplasia, which may lead to the development of type-1 ECL-cell tumours (gastric carcinoids).

Pathogenesis
Chronic corpus gastritis and autoimmune gastritis leads to hypochlorhydria, then hypergastrinaemia, then ECL-cell hyperplasia (first linear and then micronodular), then adenomatoid hyperplasia (> 5 micronodules), then ECL dysplasia, and finally to carcinoid tumour (> 0.5 mm or submucosal invasion). Reduced acidity, either surgically by vagotomy or pharmacologically by cimetidine, results in functional atrophy, changing the stomach’s flora to bugs that form N-nitroso compounds. Atrophic gastritis may be a common pathway for gastric ulcers and cancer in patients with H pylori infection.

atrophic gastritis

Gastroentrology A condition that is the end result of chronic gastritis, characterized by mucosal atrophy, which may be a precursor of gastric CA. See Helicobacter pylori, Stomach cancer.

a·troph·ic gas·tri·tis

(ā-trō'fik gas-trī'tis)
Chronic gastritis with atrophy of the mucous membrane and destruction of the peptic glands, sometimes associated with pernicious anemia or gastric carcinoma; also applied to gastric atrophy without inflammatory changes.

atrophic gastritis

Long-term (chronic) inflammation of the stomach with atrophy of the lining mucous membrane and poor or absent secretion of acid, PEPSIN and the INTRINSIC FACTOR. Loss of the intrinsic factor leads to PERNICIOUS ANAEMIA.
References in periodicals archive ?
When the surrounding gastric mucosa is scrutinized it is seen that most of it is associated with atrophic gastritis and intestinal metaplasia.
pylori , the bacteria can colonize in the gastric mucosa and stimulate a series of inflammatory reactions, which result to the development of atrophic gastritis and impair the gastric secret function.
Basilisco et al., "Plasma chromogranin A in patients with autoimmune chronic atrophic gastritis, enterochromaffin-like cell lesions and gastric carcinoids," European Journal of Endocrinology, vol.
The retrospective analysis of AM histological examinations over the period of 2001-2012 enabled to pick out children with gastroduodenitis from a group of children (n=42) who had undergone multiple (not less than 4) courses of treatment in the clinic, and over the last years were diagnosed with nonatrophic gastritis associated with Helicobacter pylori with +, ++ invasion degree, and in the last admissions they were found to have atrophic gastritis. Morphological study of AM in 42 patients with atrophic gastritis revealed IM in 11 cases.
Neutrophilic infiltrate in biopsy is strongly associated with the presence of H pylori.18 A study conducted in Kosovo involving Hp gastritis cases found atrophy in 14.9% cases and intestinal metaplasia in16.2% cases in their benign gastric lesions.19 In the current study, atrophic gastritis was found in only 0.9% cases and intestinal metaplasia in only 2.7% cases.
[16] studied 40 patients of pernicious anemia all were having chronic atrophic gastritis. Haruma et al.
pylori.sup.+] chronic atrophic gastritis (CAG) or gastric cancer (GC) individuals, when compared to the healthy volunteers (NGM) (unpublished data).
Brenner, "Association between chronic atrophic gastritis and serum antibodies to 15 Helicobacter pylori proteins measured by multiplex serology," Cancer Research, vol.
Together, these findings suggested autoimmune chronic atrophic gastritis as the underlying etiology of current presentation.
Lakhtakia et al., "Localised skin hyperpigmentation as a presenting symptom of vitamin B12 deficiency complicating chronic atrophic gastritis," Sultan Qaboos University Medical Sciences Journal, vol.
It can also lead to pernicious anaemia (PA) an autoimmune condition associated with atrophic gastritis resulting in further gastric inflammation.