atrogin-1

atrogin-1

An E3 ubiquitin ligase expressed in cardiac and skeletal muscle that directs muscle protein degradation after the muscle atrophy response has been triggered by Akt1-induced phosphorylation of FOXO, a transcription factor which also activates ubiquitin ligases and MuRF-1. Atrogin-deficient mice are resistant to muscle atrophy.
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The expression levels of two autophagy-related genes, MAP1LC3B and ATG7, and two muscle specific E3 ubiquitin ligases, atrogin-1 and muscle RING-finger protein-1 (MuRF-1) were assessed using pre-designed primers for each gene (BA055881, MAP1LC3B; BA091910, ATG7; BA048605, atrogin-1; BA091225, MuRF-1, Takara Bio Inc., Shiga, Japan).
Changes in expression of the autophagy-related genes microtubule-associated protein 1 light chain 3[beta] and autophagy related 7 in skeletal muscle of fattening Japanese Black cattle: a pilot study
While the exact mechanism underlying glucocorticoid-induced reduction in MM is unclear, augmented muscle protein breakdown via stimulation of the catabolic ubiquitin-proteasome system brought about by increased expression of atrogenes (genes, such as FOXO, Atrogin-1, and MuRF-1, involved in muscle atrophy) and attenuated muscle protein synthesis via inhibition of anabolic pathways (e.g., mTOR/S6 kinase 1, PBK/Akt, and insulin-like growth factor-l) have been observed (for a review see) (13).
Muscle loss following a single high-dose intramuscular injection of corticosteroids to treat disease flare in patients with rheumatoid arthritis
Inflammatory cytokines may lead to the inhibition of skeletal muscle protein synthesis and myoblast differentiation by activating MAFbx/ atrogin-1, eIF3-f, MyoD, and MuRf1 (35-37).
Decreased muscle strength is associated with proinflammatory cytokines but not testosterone levels in men with diabetes
(21) Vibration increased synthesis and decreased activation of the ubiquitin-proteasome pathway with myostatin and Atrogin-1 suppression, in vitro.
Vibracion corporal total en la unidad de cuidados intensivos: revision narrativa
Using RT-PCR, the expression levels of cytokines (IL-6, transforming growth factor [beta] (TGF [beta])), chemokines, and chemokine receptors C-X-C motif chemokine receptor 3 (CXCR3), interferon gamma inducible protein 10 (IP-10), and monocyte chemoattractant protein 1 (MCP-1), and the atrophy-associated gene atrogin-1 were analyzed.
NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness
O TF e um importante regulador de marcadores anabolicos e catabolicos e a pratica regular dessa atividade pode contribuir para a fosforilacao de alguns marcadores anabolicos como a via Akt/mTOR e na cascata de sinalizadores que culminam na sintese proteica como a GSK-3beta, p70S6K e 4E-BP1, alem da inibicao de marcadores catabolicos como Foxo1, Foxo3, atrogin-1 e MuRF-1 (Leger e colaboradores, 2006; Terzis e colaboradores, 2008).
TREINAMENTO DE FORCA COM BAIXAS CARGAS E ALTO VOLUME PARA HIPERTROFIA: ANALISE DE PARAMETROS MOLECULARES
Simultaneously intense exercise may stimulate the ubiquitin proteasome pathway and the induction of muscle-specific E3-ubiquitin ligases, atrogin-1 and muscle RING finger-1 (MuRF1) which promote muscle turnover (Rahbek et al., 2015; Stefanetti et al., 2014).
No effect of a whey growth factor extract during resistance training on strength, body composition, or hypertrophic gene expression in resistance-trained young men
Similarly, atrogin-1 expression was significantly increased in skeletal muscle at end-stage disease in CBA-administered, SIV-infected macaques (Molina et al.
Alcoholic myopathy: Pathophysiologic mechanisms and clinical implications
During atrophy, Atrogin-1 and MuRF-1 are the crucial muscle-specific ubiquitin ligases that direct the polyubiquitination of proteins to target them for proteolysis by the 26S proteasome [12], shifting gene expression towards a less myogenic phenotype (Atrogin-1, which degrades MyoD) or mediating sarcomeric breakdown (MuRF1, which degrades myosins) [13], which has vital significance in the research of mechanism of muscular atrophy of cancer cachexia.
Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1
Kim, "The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1," Biochemical Journal, vol.
MicroRNA as a Therapeutic Target in Cardiac Remodeling
In IBD, as in chronic inflammatory conditions, a significant reduction in plasma and muscle IGF1 can be seen in response to the elevated concentrations of TNF-alpha and IL-6, cytokines that cause GH resistance in liver and muscles, inducing downregulation of mTOR pathway with activation of ubiquitin ligands and expression of enzymes involved in protein degradation, in particular atrogin-1, MuRFl, and MUSA1 [39-41].
Nutrition and IBD: Malnutrition and/or Sarcopenia? A Practical Guide
Methods: TGF-[beta]1 and atrogin-1 expression was evaluated by RT-qPCR and/or ELISA; Smad3 phosphorylation by western blot; Smad4 nuclear translocation by indirect immunofluorescence; and ROS levels by DCF probe fluorescent measurements.
Apocynin inhibits the upregulation of TGF-[beta]1 expression and ROS production induced by TGF-[beta] in skeletal muscle cells
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