atrogin-1

An E3 ubiquitin ligase expressed in cardiac and skeletal muscle that directs muscle protein degradation after the muscle atrophy response has been triggered by Akt1-induced phosphorylation of FOXO, a transcription factor which also activates ubiquitin ligases and MuRF-1. Atrogin-deficient mice are resistant to muscle atrophy.

References in periodicals archive ?

These responses were associated with upregulation of Atrogin-1 in both muscles and C2C12 cells, and LC3 gene only in soleus.

Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents

O TF e um importante regulador de marcadores anabolicos e catabolicos e a pratica regular dessa atividade pode contribuir para a fosforilacao de alguns marcadores anabolicos como a via Akt/mTOR e na cascata de sinalizadores que culminam na sintese proteica como a GSK-3beta, p70S6K e 4E-BP1, alem da inibicao de marcadores catabolicos como Foxo1, Foxo3, atrogin-1 e MuRF-1 (Leger e colaboradores, 2006; Terzis e colaboradores, 2008).

TREINAMENTO DE FORCA COM BAIXAS CARGAS E ALTO VOLUME PARA HIPERTROFIA: ANALISE DE PARAMETROS MOLECULARES

Simultaneously intense exercise may stimulate the ubiquitin proteasome pathway and the induction of muscle-specific E3-ubiquitin ligases, atrogin-1 and muscle RING finger-1 (MuRF1) which promote muscle turnover (Rahbek et al.

No effect of a whey growth factor extract during resistance training on strength, body composition, or hypertrophic gene expression in resistance-trained young men

Similarly, atrogin-1 expression was significantly increased in skeletal muscle at end-stage disease in CBA-administered, SIV-infected macaques (Molina et al.

Alcoholic myopathy: Pathophysiologic mechanisms and clinical implications

NF-[kappa]B activation leads to increased expression of the E3 ubiquitin ligases MuRF-1 and Atrogin-1 [153] and muscle proteolysis, leading to atrophy.

Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences

Methods: TGF-[beta]1 and atrogin-1 expression was evaluated by RT-qPCR and/or ELISA; Smad3 phosphorylation by western blot; Smad4 nuclear translocation by indirect immunofluorescence; and ROS levels by DCF probe fluorescent measurements.

Apocynin inhibits the upregulation of TGF-[beta]1 expression and ROS production induced by TGF-[beta] in skeletal muscle cells

Atrogin-1, a muscle-specific Fbox protein highly expressed during muscle atrophy.

FoxO1 inhibits skeletal muscle hypertrophy through mTOR-independent mechanisms

Briefly, IGF-1 upregulates multiple intracellular signals that inhibit the secretion of several ubiquitin-proteins, including atrogin-1, FOX-1 and MuRF1, that have been suggested as primary factors evoking skeletal muscle atrophy [1].

Insulin growth factors may explain relationship between spasticity and skeletal muscle size in men with spinal cord injury

There was no age-related difference in expression of atrogin-1.

How hormonal and molecular responses to exercise differ by age

Atrogin: Protein expressed during muscle atrophy; atrogin-1 is expressed in cardiac and skeletal muscle and directs muscle protein degradation after muscle atrophy response has been triggered.

Alcohol's effects on the cardiovascular system

Taq-Man quantitative real-time PCR reactions were performed in triplicate, using an Eco Real-Time PCR System (Illumina, USA) with predesigned primer sets for mouse atrogin-1, MuRF-1, and the housekeeping gene 18S (TaqMan Assays-on-Demand, Applied Biosystems, USA).

High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis

The mRNA expression of mechanogrowth factor (MGF), mammalian target of rapamycin (mTOR), atrogin-1, and muscle RING finger-1 (MuRF-1) were quantified using real-time polymerase chain reaction on the basis of current methodology (Bustin et al.