atherothrombosis

ath·er·o·throm·bo·sis

(ath'er-ō-throm-bō'sis),
Thrombus formation in an atheromatous vessel.

atherothrombosis

[ath′ərō′thrombō′sis]
a condition in which a thrombus originates in an atheromatous blood vessel.

atherothrombosis

Clotting of blood within an artery at the site of an atheromatous plaque. Atherothrombosis is the principal cause of death in the Western world because of its complications—heart attack, stroke, limb gangrene, and ischaemic organ disease including dementia. Antiplatelet therapy to prevent atherothrombosis can reduce vascular disease mortality by 15 per cent and non-fatal vascular events by 30 per cent.
References in periodicals archive ?
One-year costs associated with cardiovascular disease in Canada: Insights from the Reduction of Atherothrombosis for Continued Health (REACH) registry.
Sanofi manufactures medications like Auvi Q for emergency treatment of allergic reactions, Aubagio for multiple sclerosis, Plavix for atherothrombosis, Clexane for thrombosis, Kynamro for homozygous familial hypercholesterolemia and approved for hypertension.
Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis.
Mechanisms of platelet activation: Need for new strategies to protect against platelet-mediated atherothrombosis.
The PARTNERS (PAD Awareness, Risk, and Treatment: New Resources for Survival) and REACH (Reduction of Atherothrombosis for Continued Health) surveys have shown a 40-60% association between PAD, coronary arterial disease and cerebrovascular disease (the strongest association being between peripheral and coronary arterial disease) (Fig.
Mean platelet volume, which is a marker for platelet activation, is a new risk indicator for atherothrombosis since increased platelet activity has been shown to contribute to the rise in the risk of cardiovascular disease associated with impaired glucose tolerance.
Department of Epidemiology, Atherothrombosis and Imaging, Fundacion Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
But CHARISMA (Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance) and MATCH (Management of ATherothrombosis with Clopidogrel in High-risk patients) large randomized clinical trials could not show any difference between dual antiplatelet therapy (aspirin and clopidogrel) and aspirin alone in primary end-point in high risk cardiovascular patients (31, 32).
In addition, elevated biomarkers of inflammation (increased IL-6, CRP) and procoagulant effects (in vivo platelet activation, elevated D-dimer) developed in asymptomatic AMAA runners during races, indicates a transient susceptibility to atherothrombosis.
The lack of a protective effect from B vitamin supplementation is disappointing, yet the error of this reductionist approach to vascular disease should not be compounded by the erroneous reductionist conclusion that homocysteine does not directly promote atherothrombosis.
Specific data such as age, sex, blood pressure and lipids were entered into the algorithm to calculate the risk of cardiac disease and events, along with data from the Reduction of Atherothrombosis for Continued Health (REACH) registry.
of Brigham and Women's Hospital, Harvard Medical School, Boston, and colleagues examined whether living alone was associated with increased mortality and cardiovascular (CV) risk in the global REduction of Atherothrombosis for Continued Health (REACH) Registry.