These cytokines initiate multiple intracellular inflammatory cascades, promoting endothelial dysfunction, vascular smooth muscle cell (VSMC) proliferation and migration leading to atherothrombosis
, hypertension and coronary artery disease (CAD).4 Hypertension is a clinical condition which effects heart and blood vessels due to persistent elevation of blood pressure (BP).
CRP also induces plasminogen Activator Inhibitor-1(PAI-1), which is a marker of disrupted fibrinolysis and atherothrombosis
. In addition, CRP is likely to increase the possibility of endothelial cells lysis and plaque erosion and can precipitate acute ischaemic stroke or coronary syndrome.
Ischemic stroke accounts for 80% of strokes and among the ischemic strokes 20-30% result from cardioembolism, 14-40% from atherothrombosis
and 15-30% from small penetrating artery disease resulting inlacunar infarcts4.
Homocysteine and atherothrombosis
. N Engl J Med 1998;338:1042-50.
Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal antiinflammatory drugs increase the risk of atherothrombosis
? Metaanalysis of randomised trials.
"While more studies are needed, the current work provides a potential new approach or target for preventing or treating heart disease in a subgroup of people who are sensitized to red meat," Ahmed Hasan, M.D., Ph.D., program director in the National Heart, Lung, and Blood Institute's Atherothrombosis
and Coronary Artery Disease Branch, said in a statement.
Obesity, non-alcoholic fatty liver disease, and atherothrombosis
: a role for the intestinal microbiota?
Adi-pocytokines in atherothrombosis
: focus on platelets and vascular smooth muscle cells.
"While more studies are needed, the current work provides a potential new approach or target for preventing or treating heart disease in a subgroup of people who are sensitized to red meat," said Ahmed Hasan, M.D., Ph.D., a medical officer and program director in NHLBI's Atherothrombosis
& Coronary Artery Disease Branch.
can lead to infarction of the brainstem and cerebellum, which comprise 20 % of all ischemic strokes (Bamford et al., 1991).
T2MIs were identified as a rise or fall in troponin above the 99% upper reference limit when a condition other than atherothrombosis
contributed to an imbalance between myocardial oxygen supply and/or demand (1).
Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis
Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial.