atherosclerotic plaque


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atherosclerotic plaque

The core lesion of atherosclerosis, beginning as a fatty streak (an ill-defined yellow lesion­, or fatty plaque), which develops well-demarcated edges that evolve to fibrous plaques (whitish lesions with a grumous lipid-rich core). With time, it becomes a complicated plaque composed of WBCs, smooth muscle cells and extracellular matrix in larger artery intimas.

atherosclerotic plaque

Cardiology The core lesion of atherosclerosis; it begins as a fatty streak, an ill-defined yellow lesion–fatty plaque, which develops well-demarcated edges that evolve to fibrous plaques, whitish lesions with a grumous lipid-rich core which, with time, becomes a complicated plaque composed of WBCs, smooth muscle cells and extracellular matrix in large artery intimas. See Complicated plaque.

Atherosclerotic plaque

A deposit of fat and other substances that accumulate in the lining of the artery wall.
Mentioned in: Atherectomy
References in periodicals archive ?
It has been shown that manipulating expression of P4H[alpha]1 affects atherosclerotic plaque stabilization, while different manipulations of P4H[alpha]1 have different influences on lesional collagen synthesis [11-13].
Tissue samples were obtained from atherectomy of coronary artery or carotid atherosclerotic plaques by surgeon during CABG.
The mechanism underlying acute coronary syndrome (ACS) involves rupture of atherosclerotic plaques, platelet aggregation, and thrombosis (5,6).
noticed that vessel wall and plaque microvessels are increased in ruptured atherosclerotic plaques, suggesting a contributory role for neovascularization of vasa vasorum in the process of plaque rupture.
Badimon, "Controlling the angiogenic switch in developing atherosclerotic plaques: possible targets for therapeutic intervention," Vascular Cell, vol.
Schoneveld et al., "Athero-express: differential atherosclerotic plaque expression of mRNA and protein in relation to cardiovascular events and patient characteristics.
microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans.
Pathology and vulnerability of atherosclerotic plaque: identification, treatment options, and individual patient differences for prevention of stroke.
Subsequently, a possible pathogenetic mechanism was identified, as this particular cell population is capable of infiltrating and destabilizing atherosclerotic plaques [16].
The text and figures that follow will review new developments in our understanding of the pathogenesis of atherosclerosis and newways that changes in atherosclerotic plaque size and volume can be measured.
[Lp-PLA.sub.2] is highly upregulated in atherosclerotic plaque; and through hydrolysis of oxidized LDL, this enzyme generates two pro-inflammatory mediators, lysophosphatidylcholine and non-esterified oxidized fatty acid.
Using a 17-segment model of the coronary arteries to assess for the presence of calcific or noncalcific plaque, the investigators calculated a total plaque score by summing the number of coronary segments with visible atherosclerotic plaque. They calculated the FRS using age, sex, total cholesterol level, HDL cholesterol level, smoking history, and blood pressure.

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