We hypothesize that selected dietary lipids, and especially oils rich in linoleic acid, may increase the atherogenicity
of environmental chemicals, such as PCBs, by cross-amplifying mechanisms leading to dysfunction of the vasculature and related tissues.
Small dense low-density lipoprotein has increased affinity for LDL receptor-independent cell surface binding sites: a potential mechanism for increased atherogenicity
Another factor responsible for atherogenicity
is oxidative modifications of LDL (Steinberg et al.
Because the conformational alterations characteristic of small, dense LDL are likely associated with increased atherogenicity
(1, 23), the low prevalence of this trait in youths is reassuring.
To identify aberrant gene expression in inflammation that is possibly involved in arsenic atherogenicity
, we used a human cDNA microarray to search for differentially expressed genes in peripheral blood lymphocytes (PBLs) from arsenic-exposed individuals.
and carcinogenicity of high-arsenic artesian well water--multiple risk factors and related malignant neoplasms of blackfoot disease.
of apoB-containing LDLs is linked to their affinity for artery wall proteoglycans.
Apo(a), because of its homology to plasminogen, may add thrombogenicity properties to the atherogenicity
A common pathogenic process involving cell proliferation has been suggested for the human carcinogenicity and atherogenicity
of long-term exposure to InAs (10).
The authors should be complimented for evaluating this atherogenicity
index to test its significance and statistical reliability in a large study with 1669 diabetic patients.
HDL] predicts particle size in HDL and LDL, which in turn predicts CHD risk, the simultaneous use of TGs and HDL-C (both readily available in a plasma lipoprotein profile) as AIP may be useful in predicting plasma atherogenicity
Pomegranate extract (POMx) decreases the atherogenicity
of serum and of human monocyte-derived macrophages (HMDM) in simvastatin-treated hypercholesterolemic patients: A double-blinded, placebo-controlled, randomized, prospective pilot study.