Animal models and ex vivo studies of human tissue indicate that PPIs might harm coronary vessels by increasing plasma levels of asymmetrical dimethylarginine
, the investigators noted.
Arnal et al., "Determination of asymmetrical dimethylarginine
by capillary electrophoresislaser-induced fluorescence," Journal of Chromatography B: Biomedical Sciences and Applications, vol.
van Guldener et al., "Handling of asymmetrical dimethylarginine
and symmetrical dimethylarginine by the rat kidney under basal conditions and during endotoxaemia," Nephrology Dialysis Transplantation, vol.
Tai, "Plasma levels of asymmetrical dimethylarginine
and adverse cardiovascular events after percutaneous coronary intervention," European Heart Journal, vol.
Blood was centrifuged for blood sugar, glycosylated haemoglobin, total cholesterol, high-density lipoprotein, low-density lipoprotein, triglyceride and asymmetrical dimethylarginine
. SPSS 15 was used to analyse data.
in renal disease: Limits of variation or variation limits?
(ADMA) and risk of acute coronary events.
Xu et al., "Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine
," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Tsao, "Asymmetrical dimethylarginine
in renal disease: limits of variation or variation limits?
They also measured increases in plasma nitric oxide levels and decreases in asymmetrical dimethylarginine
, thiobarbituric acid reactive substance, soluble Fas ligand, soluble CD40 ligand, tumor necrosis factor-alpha, interleukin (IL)-6 and IL-8.
L-arginine, NO and asymmetrical dimethylarginine
in hypertension and type 2 diabetes.