The lack of astroglial
reactivity within regions of immunological demyelination raises the question whether this treatment might just kill astrocytes.
Differential Distribution of [Beta]III in Neuronal/Neuroblastic Versus Astroglial
Giaume, "Plasticity of astroglial
networks in olfactory glomeruli," Proceedings of the National Academy of Sciences of the United States of America, vol.
Hamprecht, "The glutathione system of peroxide detoxification is less efficient in neurons than in astroglial
cells," Journal of Neurochemistry, vol.
We previously reported that the EP3 receptor was localized to astroglial
end feet around microvessels .
Risk of childhood brain tumor in offspring associated with exclusive use of well water during pregnancy among Seattle area subjects with selected characteristics(a) Cases Controls (n = 118) (n = 247) OR(b) 95% CI Dietary characteristic Prenatal vitamins None used 4/19 2/31 9.7 1.0-120 Used prenatal vitamins 14/108 14/216 2.2 0.9-5.0 Cured meats consumed < 5 servings/week 10/82 14/197 1.8 0.7-4.4 [is greater than 8/36 2/50 6.9 1.2-69 or equal to] 5 servings/week Histologic category Astroglial
tumors 9/66 11/122 1.6 0.6-4.4 PNET 3/23 1/59 8.7 0.6-464 Other 6/29 4/66 4.0 0.9-21 (a) Restricted to cases and controls reporting either well or public water as the sole source of residential water.
Adame et al., "Astroglial
activation of extracellular-regulated kinase in early stages of Alzheimer disease," Journal of Neuropathology & Experimental Neurology, vol.
Its mode of action is to attenuate microglial and astroglial
mediated neuroinflammation, resulting in reduced burden of neuropathic proteins such as superoxide dismutase-1, alpha-synuclein and beta-amyloid in animal models of neurodegenerative disorders such as ALS, Parkinson's disease and Alzheimer's disease, respectively.
GFAP reactivity (Figure 1, panel C) confirmed the strong astroglial
activation consisting of variably enlarged protoplasmic astrocytes which could be binucleated or multinucleated up to a bizarre appearance.
"The role of Foxg1 in this transition process and its involvement in disorders such as the variants of the Rett and West syndrome suggests that some of the anomalies typical of these syndromes are generated by an alteration of the time scale with which the astroglial
cells are generated and opens the way to possible gene therapies."
S100b protein is present in high concentrations in astroglial
cells and white matter besides being produced in Schwann cells and peripheral nerve cells.
Cerebrospinal fluid promotes survival and astroglial
differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation.