Sperm motility inversely correlates with seminal leptin levels in idiopathic asthenozoospermia
Thus, a possible pathogenic role in infertile men when asthenozoospermia
is the main critical problem may be cured; however, this should be proven scientifically.
Exclusion criteria included aspermia, oligozoospermia, hypospermia, asthenozoospermia
, samples not produced via masturbation, contaminated samples, patients who were on medication that may affect semen parameters and patients younger than 18 years of age.
Sperm phosphoproteome profiling by ultra performance liquid chromatography followed by data independent analysis (LC-MS(E)) reveals altered proteomic signatures in asthenozoospermia
OncBioMune Pharmaceuticals, Inc (OncBioMune or the Company), a revenue-stage biopharmaceutical company engaged in the development of targeted cancer therapies and a proprietary vaccine technology and commercialization of a portfolio of products internationally, is pleased to report that the Companys licensed male fertility product Andfrt demonstrated a clinically meaningful benefit in treating asthenozoospermia
, a medical condition defined by abnormal sperm motility.
It is known that asthenozoospermia
(poor/dysfunctional sperm motility) is the commonest disorder in male infertility, yet there is no drug that men can currently take for it to improve the chances of conception.
Patients who are at risk of seminal oxidative stress, sperm DNA damage and apoptosis are of idiopathic infertility, genital tract infections, varicocele, teratozoospermia, asthenozoospermia
, azoospermia and smoking.
In contrast, if no detectable color change is observed, then that patient may be at high risk for azoospermia, oligozoospermia, necrozoospermia, or asthenozoospermia
Nevertheless, it remains unknown whether the differences in ROS and capacitation levels after serum supplementation affect the fertilization potential of spermatozoa from patients with inadequate sperm parameters, such as oligozoospermia, asthenozoospermia
, and teratozoospermia.
Zinc therapy in men with asthenozoospermia
resulted in a significant increase in sperm concentration, progressive motility, sperm integrity and improved conception and pregnancy rates (Omu et al.
In sperm counts greater than 350 x 106 /mL, polyzoospermia may be associated with asthenozoospermia
and/or teratozoospermia (Andrade- Rocha, 1994).
Oral administration of L-carnitine in human with idiopathic asthenozoospermia
also demonstrated the improvement of spermatozoa quality (Costa et al.