The two compounds are already marketed as the drugs tacrolimus and astemizole
Kaletra should not taken with any of the following medicines: astemizole
, terfenadine, oral midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, and methylergonovine, amiodarone, lovastatin, simvastatin, vardenafil, sildenafil used to treat pulmonary arterial hypertension and products containing St.
Dual effect of the anti-allergic astemizole
Initial reports of cardiac arrhythmias, including torsades de pointes, were predominately associated with high blood concentrations subsequent to overdoses Given the metabolic pathway of these drugs, arrhythmias were eventually reported subsequent to coadministration with drugs that slowed the metabolism of terfenadine and astemizole
(also resulting in high blood concentrations).
Coadministration is contraindicated for ergot alkaloids, terfenadine, astemizole
, cisapride, pimozide, halofantrine, and quinidine.
When they gave the animals a drug called astemizole
, which blocks the gene, it almost completely stopped wastage in muscles that were not being used.
The screening identified the antihistamine astemizole
, which was removed from American and European markets in the late 1990s because of potential damage to the heart.
Patients were given 5, 10, or 20 mg/day of astemizole
for 13 weeks.
grepafloxacin (Raxar), terfenadine (Seldane), cisapride (Propulsid), and astemizole
Interacts with several drugs, including terfenadine, astemizole
, and cisapride, resulting in prolonged QT intervals.
More than 100 million prescriptions were written for terfenadine and astemizole
before they were withdrawn from the market because of torsades and sudden death.
Name of products Acidum pipemidig Atenolol Albendazol Amineptina Aciclovir Acid clavulanic Astemizole
Aztreonam Bacampicillin Budesonide Bitolterol mesylate Bromcriptine masylate Bifonazol Cyclosporin Cefadroxil monohydrat Cefotaxime sodium Cyclopirox olamine Cytarabine Hcl Cetraxate Hcl Cefsulodin sodium Cefoperazone Domperidon Estazolam Fentiazac Isoconazol Ipratropium bromide Ifosfamide Ketoconazol Labetalol Hcl Minoxidil Miconazol Metroprolol tartrat Metrizamide Mianserin Hcl Midazolam malfate Metilmicin SO4 Nadolol Nicardipine Hcl Nor floxacin Oxatomide Piroxicam Praziquantel Procaterol Hcl Prazosin Hcl Sisomicin sulfat Sulprostone Tiemonium metil SO4 Tioconazole Vindesine SO4 Vecuronium bromide