asporin

asporin

A protein found in the extracellular matrix that decreases cartilage production and the accumulation of proteoglycans.
References in periodicals archive ?
The data available was for the 7 SLRP proteins that were found to be downregulated in the high PWV patients, namely, lumican, mimecan, prolargin, asporin, podocan, decorin, and biglycan [9].
Hydrated Dehydrated Dehydrated Dehydrated media media adventitia media and adventitia Number of n 14 17 17 17 patients PWV r 0.63 0.62 0.56 0.62 p 0.017 * 0.008 ** 0.02 * 0.009 ** Number of n 12 12 12 12 patients Lumican r -0.71 -0.20 -0.50 -0.30 p 0.01 ** 0.54 0.10 0.34 Mimecan r -0.54 -0.02 -0.45 -0.22 p 0.07 0.95 0.15 0.50 Prolargin r -0.72 -0.48 -0.52 -0.38 p 0.008 ** 0.12 0.09 0.23 Asporin r -0.62 -0.51 -0.39 -0.37 p 0.033 * 0.09 0.21 0.24 Podocan r -0.48 -0.27 -0.34 -0.18 p 0.11 0.39 0.28 0.57 Decorin r -0.63 -0.22 -0.34 -0.22 p 0.028 * 0.48 0.29 0.48 Biglycan r -0.15 -0.12 -0.20 -0.07 p 0.63 0.71 0.53 0.83
Iida et al., "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis," Nature Genetics, vol.
Specific proteins, such as asporin and tenomodulin, were limited to tendons, while versican, proteoglycan 4, and SOD3 were ligament-specific (Figure 1).
EntrezID Gene full name Gene CombinedRP symbol 1293 Collagen type VI alpha 3 chain COL6A3 59.02 1278 Collagen type I alpha 2 chain COL1A2 62.06 10562 Olfactomedin 4 OLFM4 150.67 7058 Thrombospondin 2 THBS2 163.66 115908 Diffuse panbronchiolitis CTHRC1 174.61 critical region 1 4680 Collagen triple helix repeat CEACAM6 203.78 containing 1 3624 Inhibin beta A subunit INHBA 219.12 1290 Collagen type V alpha 2 chain COL5A2 230.72 54829 Asporin ASPN 255.15 1366 Claudin 7 CLDN7 288.09 EntrezID AveLogFC 1293 3600.96 1278 3576.21 10562 3542.76 7058 24.03 115908 1204.56 4680 2542.02 3624 368.69 1290 1064.68 54829 237.05 1366 356.71
The ASPN gene encodes a 382 amino-acid protein, asporin. Asporin is a member of the sub family of small leucine-rich proteoglycans that also includes decorin and biglycan.
Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family.
Binding characteristics of the osteoarthritis-associated protein asporin. J Bone Miner Metab 2010;28:395-402.
TABLE 1: FACTORS REGULATING PERIODONTAL LIGAMENT HOMEOSTASIS Cellular Factors Biochemical Factors Genetic Mechanical Factors Factors * Mesenchymal stem * Osteocalcin * Runx2 cells * Bone sialoprotein * Msx2 * Epithelial cell * Glycosaminoglycans * Twist gene rests * Osteonectin * Fibroblasts * Nitrous oxide * Osteoprotegrin * Prostaglandins * Cytokines * Growth Factors * Periostin * S100A4 * RGD-CAP * Asporin
Mass spectrometryanalysis of tissue extracts identified only 5 of the candidate biomarkers in the samples analyzed: apolipoprotein C1 (APOC1, gel 8), asporin (ASPN, gel 5), complement C4A (gel 8), 6-phosphogluconolactonase (PGLS, gel 7), and ribosomal protein L22-like 1 (RPL22L1, gel 8).
However, we failed to identify asporin, fibronectin, matrilin, osteomodulin, podocan, reelin, or vitronectin in any protostome animals, suggesting that these ECM proteins may have originated within the Deuterostomia.
protostome) using human genes implicated in wound healing in the initial query Extracellular matrix ID Protostome E proteins hit value Human query SLRPs (small leucine-rich-repeal proteins) Biglycan AAA52287 XM_001649763 3e-21 Chondroadherin AAK51556 XM_970227 3e-26 Decorin AAB60901 No match n/a Fibrinidulin CAA53233 AJ549813 9e-21 Keratocan NP_008966 XM_001650288 8e-16 Lumican AAA91639 XM_395331 3e-17 Opticin CAB53459 XM_001606218 4e-11 Osteoglyein CAI16695 NM_206253 4e-04 PRELP CAG47066 XM_001360484 2e-15 Other extraceluar matrix proteins Asporin CAI16697 XM_967172 2e-28 Dermatan Sulf.