aspirin-induced asthma


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aspirin-induced asthma

A condition characterised by a triad of asthma, aspirin sensitivity and nasal polyps, affecting up to 10% of asthmatics and usually presenting by age 30 to 40. A single dose of aspirin or, less commonly, other NSAIDs can provoke an acute asthmatic attack with rhinorrhoea, conjunctival irritation, and flushing of the head and neck due to post-exposure increase of eosinophil and secretion of cysteinyl leukotrienes.

Management
Avoid trigger agents; leukotriene antagonists may help.
References in periodicals archive ?
Originally called aspirin-induced asthma, NSAID-exacerbated respiratory disease has long been recognised as an adverse effect, affecting about one in 10 adults who have moderate to severe asthma or rhinosinusitis with nasal polyps.
Investigators, "Natural history of aspirin-induced asthma," European Respiratory Journal, vol.
Aspirin-induced asthma (AIA) is a unique clinical syndrome, though its exact pathogenesis remains unclear.
Aspirin-induced asthma (AIA) occurs after ingestion of acid nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and indomethacin [42, 43].
Antileukotrienes are particularly useful in controlling asthma resulting from certain triggers, including exercise-induced asthma, aspirin-induced asthma and, to a lesser extent, allergen-induced asthma.
These agents have found niche applications in the treatment of allergic rhinitis, exercise- and aspirin-induced asthma, and as add-on therapy in patients with asthma poorly controlled byinhaled corticosteroid (ICS) monotherapy or ICS in combination with long-acting [beta]2-agonists [4, 5].
(7.) Lee TH, Christie PE, Leukotrienes and aspirin-induced asthma. Thorax Editorial.
(6) It has been said that because of their various characteristics, they would be particularly suited for the treatment of asthma in children, for the treatment of asthmatic patients with associated severe allergic rhinitis, for the treatment of exercise-induced bronchospasm and for aspirin-induced asthma. (6,11)
Increased excretion of leukotriene FA during aspirin-induced asthma. J Lab Clin Med 1992; 119(1):48-51.
Only about 15%-20% of the population seeking arthritis pain treatment met the criteria for receiving a selective COX-2, which included having a history of GI bleeding, major ulcerative disease, major inflammatory bowel disease, current use of warfarin, or a history of aspirin-induced asthma, which is a contraindication for conventional NSAID use.

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