aspirin-induced asthma


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aspirin-induced asthma

A condition characterised by a triad of asthma, aspirin sensitivity and nasal polyps, affecting up to 10% of asthmatics and usually presenting by age 30 to 40. A single dose of aspirin or, less commonly, other NSAIDs can provoke an acute asthmatic attack with rhinorrhoea, conjunctival irritation, and flushing of the head and neck due to post-exposure increase of eosinophil and secretion of cysteinyl leukotrienes.

Management
Avoid trigger agents; leukotriene antagonists may help.
References in periodicals archive ?
Aspirin-induced asthma (AIA) occurs after ingestion of acid nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and indomethacin [42, 43].
Antileukotrienes are particularly useful in controlling asthma resulting from certain triggers, including exercise-induced asthma, aspirin-induced asthma and, to a lesser extent, allergen-induced asthma.
6) It has been said that because of their various characteristics, they would be particularly suited for the treatment of asthma in children, for the treatment of asthmatic patients with associated severe allergic rhinitis, for the treatment of exercise-induced bronchospasm and for aspirin-induced asthma.
Increased excretion of leukotriene FA during aspirin-induced asthma.
Only about 15%-20% of the population seeking arthritis pain treatment met the criteria for receiving a selective COX-2, which included having a history of GI bleeding, major ulcerative disease, major inflammatory bowel disease, current use of warfarin, or a history of aspirin-induced asthma, which is a contraindication for conventional NSAID use.
Controversy surrounds the extent of aspirin-induced asthma, with most figures estimating the risk at about 10pc of asthmatics.
The researchers said that a greater understanding of aspirin-induced asthma was needed, particularly because consumers tended to self-prescribe.
They discovered that 21 per cent of the adults and five per cent of the children had aspirin-induced asthma syndrome.
In aspirin-induced asthma, cysteine-leukotriene release into airways (3, 4) is associated with increased concentrations of leukotriene C4 synthase, the enzyme that forms leukotriene C4 [for review, see Ref.

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