Originally called aspirin-induced asthma
, NSAID-exacerbated respiratory disease has long been recognised as an adverse effect, affecting about one in 10 adults who have moderate to severe asthma or rhinosinusitis with nasal polyps.
Investigators, "Natural history of aspirin-induced asthma
," European Respiratory Journal, vol.
(AIA) is a unique clinical syndrome, though its exact pathogenesis remains unclear.
(AIA) occurs after ingestion of acid nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and indomethacin [42, 43].
Antileukotrienes are particularly useful in controlling asthma resulting from certain triggers, including exercise-induced asthma, aspirin-induced asthma
and, to a lesser extent, allergen-induced asthma.
These agents have found niche applications in the treatment of allergic rhinitis, exercise- and aspirin-induced asthma
, and as add-on therapy in patients with asthma poorly controlled byinhaled corticosteroid (ICS) monotherapy or ICS in combination with long-acting [beta]2-agonists [4, 5].
Is coronary arterial spasm part of the aspirin-induced asthma
(7.) Lee TH, Christie PE, Leukotrienes and aspirin-induced asthma
. Thorax Editorial.
(6) It has been said that because of their various characteristics, they would be particularly suited for the treatment of asthma in children, for the treatment of asthmatic patients with associated severe allergic rhinitis, for the treatment of exercise-induced bronchospasm and for aspirin-induced asthma
Increased excretion of leukotriene FA during aspirin-induced asthma
. J Lab Clin Med 1992; 119(1):48-51.
Only about 15%-20% of the population seeking arthritis pain treatment met the criteria for receiving a selective COX-2, which included having a history of GI bleeding, major ulcerative disease, major inflammatory bowel disease, current use of warfarin, or a history of aspirin-induced asthma
, which is a contraindication for conventional NSAID use.