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An alkaloid obtained from quebracho, an irritant.
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Isoholograms were obtained and demonstrated a synergic effect of N-formyl-aspidospermidine and aspidospermine when associated with chloroquine.
1996), we have tested two of the most active ones, N-formyl aspidospermidine 3 and aspidospermine 5, in association with chloroquine, in order to determine the existence of a possible cumulative effect between these molecules.
The demethylation of aspidospermine was performed according to a method described by Janot and Goutarel, 1957.