Use of doxorubicin in clinical practice is hindered by emergence of wide variety of its side effects on non-targeted tissues leading to organopathies and causes toxicity to both somatic and germ cell in reproductive tissue resulting in testicular atrophy and aspermatogenesis
.5 Testes are paired male reproductive organ in scrotal sac for production of spermatozoa, histologically consist of seminiferous tubules and interstitial spaces having leydig cells.
in the guinea pig induced by testicular tissue and adjuvants," The Journal of Experimental Medicine, vol.
These defects included; vacuolated degeneration of the spermatogenic cells, presence of necrotic cells inside the degenerative tubule, aspermatogenesis
(Fig.1D), edema between the seminiferous tubule and hyalinization inside the tubule (Fig.1D), increase in apical sloughing (Fig.1B) Separation of spermatogenic cells from the germinal epithelial membrane (Fig.1C), exfoliation of spermatocytes in the lumen of some tubule (Fig.1B).
Syndrome characterized by gynecomastia, aspermatogenesis
without A-Leydigism, and increased excretion of follicle-stimulating hormone.