Candida secreted aspartyl
proteinases - expression and function during infection.
ALP: Alkaline phosphatase; AST: Aspartyl
aminotransferase; ALT: Alanine aminotransferase.
albicans, which though distantly related have similar gene families encoding for enzymes phospholipases, lipases, aspartyl
proteases, and acid sphingomyelinases.
The predominant in vivo proton signal is NAA, with contributions from other N-acetyl compounds, especially N-acetyl aspartyl
Notably, the CTX octapeptide also contains an aspartyl
that gradually undergoes isomerization and racemization, converting from the newly synthesized form ([alpha]CTX) to an isomerized form ([beta]CTX) over time.
Cathepsin D is a lysosomal aspartyl
protease which acts as a mature active enzyme in the lysosomes in an acidic pH and synthesized by stromal reactive cells and macrophages.
Clarke, Deamidation, isomerization, and racemization at asparaginyl and aspartyl
residues in peptides.
proteinases (SAPs) are extracellular proteolytic enzymes that play a central role in Candida pathogencity.
protease beta-secretase (BACE1) is responsible for the first step in the proteolytic pathway that produces these peptides in the brain.
The [beta]-secretase (BACE1, transmembrane aspartyl
protease) initiates endoproteolytic cleavage giving rise to N-terminus of A[beta] ([beta]-secretase cleaved APP to [beta]CTF as the intermediate) followed by [gamma]-secretase (membrane-embedded aspartyl
protease complex consisting of presenilin, PS), presenilin enhancer-2 (Pen-2), anterior pharynx defective-1 (Aph-1), and nicastrin, which reveals the C-terminus of A[beta] .
proteases, phospholipases, and lipases are involved in the breakdown of cell membranes in host epithelia, which promotes colonization and invasion .
Renin is an aspartyl
protease which specifically cleaves angiotensinogen.