aspartate transaminase

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Related to aspartate transaminase: Alanine transaminase

aspartate transaminase

 (AST) (ASAT) [ah-spahr´tāt trans-am´ĭ-nās]
an enzyme that catalyzes the reversible transfer of an amino group from aspartate to α-ketoglutarate to form glutamate and oxaloacetate, requiring the coenzyme pyridoxal phosphate; it is normally present in serum and in various body tissues, especially in the heart and liver. (See accompanying table.) It is released into the serum as the result of tissue injury, especially injury to the heart or liver, hence the concentration in the serum may be increased in myocardial infarction or acute damage to hepatic cells. Serum levels are also increased in some muscle diseases, such as progressive muscular dystrophy. Called also glutamic-oxaloacetic transaminase.

as·par·tate a·mi·no·trans·fer·ase (AST),

an enzyme catalyzing the reversible transfer of an amine group from l-glutamate to oxaloacetate, forming α-ketoglutarate and l-aspartate; an aid in diagnosing viral hepatitis and myocardial infarction.

aspartate transaminase

/as·par·tate trans·am·i·nase/ (AST) (ASAT) (trans-am´ĭ-nās) an enzyme normally present in body tissues, especially in the heart and liver; it is released into the serum as the result of tissue injury, hence the concentration in the serum (SGOT) may be increased in disorders such as myocardial infarction or acute damage to hepatic cells.

aspartate transaminase


Asp; any salt of aspartic acid; aspartic acid in dissociated form.

aspartate carbamoyl transferase
enzyme catalyzing the condensation of carbamoyl phosphate and l-aspartate to N-carbamoyl-l-aspartate. A regulatory, allosteric enzyme in the synthesis of pyrimidine nucleotides.
aspartate transaminase

Patient discussion about aspartate transaminase

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References in periodicals archive ?
The supernatant was used for estimating aspartate transaminase (AST), alanine transaminase (ALT) (Wooten, 1964), acid phosphatase (ACP) and alkaline phosphatase (ALK) (Garen and Levinthal, 1960).
com)-- Bioo Scientific announced the availability of the MaxDiscovery[TM] Aspartate Transaminase (AST) and Lactate Dehydrogenase (LDH) Color Endpoint Assays which use a proprietary, innovative technology for visible detection of in vivo toxicity using only 5 [micro]L of serum from rodents or other mammals.
Enzymes of the liver were in the normal range: aspartate transaminase 151 [micro]kat/L (normal to 567 [micro]kat/L), ALT: 428 [micro]kat/L (normal to 750 [micro]kat/L).
B-A reduces the elevated levels of serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), [gamma]-glutamyl transferase ([gamma]-GT), lactate dehydrogenase (LDH), 5' nucleotidase (5'ND).
9]/l; mean cell volume 82 fl; peripheral smear showed anisocytosis, target cells and schistocytes; lactate dehydrogenase 612 U/l; alanine transaminase 446 U/l; aspartate transaminase 191 U/l; total bilirubin 34 mmol/l; direct bilirubin 12 mmol/l; total protein 46 g/l; albumin 20 g/dl; international normalised ratio 2.
There's albumin and globulin and aspartate transaminase, and 5' nucleotidase, gamma glutamyl transpeptidase and lactate dehydrogenase, and alanine transaminases.
Chronic HBV is defined as the presence of hepatitis B surface antigen (HBsAg) for longer than 6 months, more than 2,000 IU/mL of serum HBV DNA, elevated aspartate transaminase (AST)/alanine transaminase (ALT) levels, and a liver biopsy showing chronic hepatitis with at least moderate necrosis/inflammation.
His blood glucose was 147 mg/dL; serum alanine transaminase, 1,877 U/L; serum aspartate transaminase, 2,612 U/L; alkaline phosphatase, 125 U/L; [gamma]-glutamyl transferase, 113 U/L; total bilirubin, 1.
Withdrawal of the drug is indicated if serum levels of aspartate transaminase and alanine transaminase are three or more times higher than normal.
Aspartate transaminase and alanine transaminase may also be elevated in an alcoholic patient, with the AST value generally higher than the ALT value.
Liver blood tests showed statistically significant improvements in alanine transaminase (ALT), aspartate transaminase (AST) and bilirubin values in the GATTEX-treated group versus placebo.