aspartate aminotransferase


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as·par·tate a·mi·no·trans·fer·ase (AST),

an enzyme catalyzing the reversible transfer of an amine group from l-glutamate to oxaloacetate, forming α-ketoglutarate and l-aspartate; an aid in diagnosing viral hepatitis and myocardial infarction.

aspartate aminotransferase (AST)

[aspär′tāt]
an enzyme normally present in body serum and in certain body tissues, especially those of the heart and liver. This enzyme affects the intermolecular transfer of an amino group from aspartic acid to alpha-ketoglutaric acid, forming glutamic acid and oxaloacetic acid. The reaction is reversible. The enzyme is released into the serum because of tissue injury and thus may increase as a result of myocardial infarction and liver damage. Normal findings for adults are 8 to 20 U/L or 5 to 40 IU/L. Previously called glutamic-oxaloacetic transaminase, serum glutamic oxaloacetic transaminase (SGOT). Compare alanine aminotransferase.

aspartate aminotransferase

GOT, glutamate oxaloacetate transaminase AST A cytoplasmic and mitochondrial transaminase enzyme that catalyzes the reaction of aspartate and 2-oxoglutarate yielding glutamate and oxaloacetate; the transport of amino acids is central to protein buildup-anabolism or breakdown-catabolism; AST is ↑ in hepatic, myocardial, renal and cerebral infarction, and in hepatic and skeletal muscle disease

as·par·tate a·mi·no·trans·fer·ase

(AST) (as-pahr'tāt ă-mē'nō-trans'fĕr-ās)
An enzyme catalyzing the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming α-ketoglutaric acid and l-aspartic acid; a diagnostic aid in viral hepatitis and in myocardial infarction.
Synonym(s): glutamic-oxaloacetic transaminase, serum glutamic-oxaloacetic transaminase.

aspartate aminotransferase

One of the enzymes released into the blood when tissue, such as liver or heart muscle, is damaged. Measurement of the level of such enzymes gives a useful indication of the extent of the damage.

aspartate aminotransferase

an enzyme that catalyzes the reversible transfer of an amino group:
$$\eqalign{\hbox{aspartic acid + \alpha-ketoglutaric acid }\cr \hbox{\quad\leftrightharpoonsarrow\,\! oxaloacetic acid + glutamic acid}}$$
requiring the coenzyme pyridoxal phosphate; abbreviated AST. It is present in many tissues and body fluids. The serum concentration is elevated when damage to tissue cells, especially of the heart and liver, causes a release of the enzyme. AST values are also increased in some muscle diseases, such as enzootic muscular dystrophy. The test has limitations because of its lack of organ specificity. Called also (serum) glutamic-oxaloacetic aminotransferase (GOT or SGOT).

Patient discussion about aspartate aminotransferase

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References in periodicals archive ?
Aspartate aminotransferase criteria: acceptable laboratory-defined difference, [less than or equal to] 21%; critical difference (CLSI), [less than or equal to] 13%; [CV.
Macro-AST: a benign cause of persistently elevated aspartate aminotransferase.
Total cholesterol, LDL-cholesterol, blood urea nitrogen (BUN), creatinine, and uric acid were markedly higher in patients with ESRD than in age- and sex-matched controls, whereas ABI, HDL-cholesterol, total protein, albumin, aspartate aminotransferase, and alanine aminotransferase were markedly lower in ESRD patients.
Blood chemistry values included raised enzymes: 1,858 IU/L lactate dehydrogenase (LDH), 283 IU/L aspartate aminotransferase (AST), 210 IU/L alanine aminotransferase (ALT), 672 IU/L creatine phosphokinase, and 84 IU/L [gamma]-glutamyl transaminase.
Presumptive diagnosis of exertional myopathy was based on history of recent capture or trauma, clinical signs, and elevation of aspartate aminotransferase, alanine aminotransferase, creatine kinase, lactate dehydrogenase, and serum potassium.
They retrospectively compared 342 patients with elevated serum alanine aminotransferase or aspartate aminotransferase values who were prescribed a statin with 1,437 patients who were prescribed a statin but had normal liver enzyme levels and 2,245 patients who did not take any statins but had elevated liver enzymes.
In the 6 patients seen during the first week of symptoms (acutely ill patients), lymphopenia was present in 67%, thrombocytopenia in 50%, and increase of alanine aminotransferase/ aspartate aminotransferase in 67%.
Significant differences between age groups were identified in glucose, potassium, phosphorus, calcium, albumin, total plasma protein, globulin, cholesterol, bile acid, and zinc concentrations, as well as aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, and creatine phosphokinase activities (P < .
Pearson, the addition of 10 mg of ezetimibe daily to existing statin regimens for 6 weeks led to no statistically significant changes in the incidence of metabolic abnormalities of the liver or muscle tissue, as measured by serum levels of alanine aminotransferase, aspartate aminotransferase, and creatine kinase.
Contract awarded for code 12647 aspartate aminotransferase (ast), reagent for the determination test.