aspartate aminotransferase

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as·par·tate a·mi·no·trans·fer·ase (AST),

an enzyme catalyzing the reversible transfer of an amine group from l-glutamate to oxaloacetate, forming α-ketoglutarate and l-aspartate; an aid in diagnosing viral hepatitis and myocardial infarction.
Farlex Partner Medical Dictionary © Farlex 2012

aspartate aminotransferase

GOT, glutamate oxaloacetate transaminase AST A cytoplasmic and mitochondrial transaminase enzyme that catalyzes the reaction of aspartate and 2-oxoglutarate yielding glutamate and oxaloacetate; the transport of amino acids is central to protein buildup-anabolism or breakdown-catabolism; AST is ↑ in hepatic, myocardial, renal and cerebral infarction, and in hepatic and skeletal muscle disease
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

as·par·tate a·mi·no·trans·fer·ase

(AST) (as-pahr'tāt ă-mē'nō-trans'fĕr-ās)
An enzyme catalyzing the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming α-ketoglutaric acid and l-aspartic acid; a diagnostic aid in viral hepatitis and in myocardial infarction.
Synonym(s): glutamic-oxaloacetic transaminase, serum glutamic-oxaloacetic transaminase.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

aspartate aminotransferase

One of the enzymes released into the blood when tissue, such as liver or heart muscle, is damaged. Measurement of the level of such enzymes gives a useful indication of the extent of the damage.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Patient discussion about aspartate aminotransferase

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References in periodicals archive ?
Mean [+ or -] SD (U/L) of Aspartate Aminotransferase (AST) in CKD Patients and Healthy Controls Subjects AST (U/L) Predialysis CKD 16.87 Parients Hemodialysis CKD 14.49 Patients Normal Healthy 17.34 Controls Note: Table made from bar graph.
In the present study, the feed/gain and aspartate aminotransferase showed a quadratic response to increasing supplemental pyridoxine levels (p = 0.0114 and p = 0.0385) and homocysteine showed quadratic trend as this vitamin level increased (p = 0.0538).
Gingival crevicular fluid levels of aspartate aminotransferase, sulphide ions and N benzoyl-Dl-arginine-2-naphtylamide in diabetic patients with chronic periodontitis.
(19) Elevated levels of alanine aminotransferase and aspartate aminotransferase may suggest hepatic injury, but these elevations along with significantly elevated levels of creatine phosphokinase, lactate dehydrogenase, and a high ratio of aspartate aminotransferase to alanine aminotransferase should indicate the correct diagnosis of rhabdomyolysis.
However, three other levels were slightly elevated: aspartate aminotransferase: 19 U/L (normal: 3 to 18); alanine aminotransferase: 25 U/L (normal: 3 to 22); and lactate dehydrogenase: 264 U/L (normal: 40 to 240).
The DNA sequence and characteristics of cDNA clones encoding cytosolic (Gebhardt et al., 1999) and plastidic aspartate aminotransferase (Wadsworth et al., 1993), aspartokinase homoserine dehydrogenase (Gebhardt et al., 1998), dihydrodipicolinic acid synthase (Silk et al., 1994), asparagine synthetase (Hughes et al., 1999), and a 34-kDa protein (Kalinski et al., 1990) were reported previously.
Over 50% of those receiving IL-2 experienced grade 3 adverse events including asthenia (weakness), fever, arthralgia (pain in the joints), myalgia (muscle pain) and increased levels of bilirubin, alanine aminotransferase and aspartate aminotransferase. The clinical benefits of the addition of IL-2 to antiretroviral therapy have yet to be evaluated.
As previously reported, one patient experienced slight elevations in aspartate aminotransferase, or AST, which quickly resolved without any additional treatment or loss of FIX activity.
The most common adverse reactions reported in patients treated with ALUNBRIG at the recommended 180 mg dosing regimen were increased aspartate aminotransferase, hyperglycemia, hyperinsulinemia, anemia, increased creatine phosphokinase, nausea, increased lipase, decreased lymphocyte count, increased alanine aminotransferase, diarrhea, increased amylase, fatigue, cough, headache, increased alkaline phosphatase, hypophosphatemia, increased abnormal activated partial thromboplastin time, rash, vomiting, dyspnea, hypertension, decreased blood cell count, myalgia, and peripheral neuropathy.
In one of our previous publications we have concluded that raised serum bilirubin, unconjugated bilirubin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were predictors of mortality in patients with mushroom poisoning.
The multivariable analysis also linked physical activity to an average 3.30-IU/L drop in alanine aminotransferase levels (95% CI, -5.57 to -1.04) and to a 4.9-IU/L decrease in aspartate aminotransferase levels (95% CI, -8.68 to -1.02).