Kinetics of deamidation of an asparaginyl
residue in a model hexapeptide.
Deamidation of glutaminyl and asparaginyl
residues in peptides and proteins.
Objective: This project entitled Synthesis of Truncated tirandamycin A-D derivatives as new Antihelminthic Agents (STTDAA) aims at developing novel asparaginyl
tRNA synthetase (AsnRS) inhibitors as potential antihelminthic agents, with new mechanisms of action for potential treatment of lymphatic filariasis (LF).
Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl
hydroxylation of ankyrin repeat domain-containing proteins.
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl
Stability of adrenocorticotropic hormone (ACTH) and pathways of deamidation of asparaginyl
residue in hexapeptide segments.
Clarke, Deamidation, isomerization, and racemization at asparaginyl
and aspartyl residues in peptides.
The hydroxylation is catalyzed by a variety of nonheme iron-containing dioxygenases, including prolyl, asparaginyl, and lysyl hydroxylases (Hewitson et al.
Among them are two long-known collagen prolyl-4-hydroxylases (Myllyharju 2003), the more recently identified FIH-1 (factor inhibiting HIF), and PHD1-3, asparaginyl and prolyl hydroxylases, responsible for HIF-[alpha] protein hydroxylation (Epstein et al.
The stability and degradation pathway of recombinant human parathyroid hormone: deamidation of asparaginyl
residue and peptide bond cleavage at aspartyl and asparaginyl
9-Da marker peptide appeared in the Hb variant [[beta]66 Lys[right arrow]Asn] only, but not in wild-type Hb, and was confirmed to be an amino acid substitution by elimination of the tryptic cleavage site at Lys([beta]66) and by the characteristic mass increase of 114 Da, which indicated the addition of an asparaginyl
residue to this position.
Structure of the EF corner favors deamidation of asparaginyl
residues in hemoglobin: the example of Hb La Roche-sur-Yon [[beta]81(EF5)Leu [right arrow] His].