ALG14(redirected from asparagine-linked glycosylation 14 homolog)
ALG14A gene on chromosome 1p21.3 that encodes a subunit of a bipartite UDP-N-acetylglucosamine transferase, which heterodimerises with asparagine-linked glycosylation 13 homolog to form a functional UDP-GlcNAc glycosyltransferase. This enzyme catalyses the second sugar addition of the conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation; with ALG13, this transferase catalyses asparagine (N)-glycosylation, an essential modification that regulates protein folding and stability.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.