21,22,23] laser therapy,  cryotherapy, [25,26,27] interferon,  Radiation, [29,30] Asiaticoside
The primary constituents are triterpenic acid sugar esters: asiaticoside
, asiatic acid, madecassoside and madecassic acid (Singh and Rastogi, 1969); because of their abundance and importance, these constituents are used as biomarker to uphold quality assurance of the C.
Drug interaction between asiaticoside
and some anti inflammatory drugs in wound healing of the rat.
A preliminary phytochemical screening of the extract revealed that the major components are the triterpenes--asiatic acid and madecassic acid, and their derived triterpene ester glycosides, asiaticoside
, madecassoside, and centelloside.
Based on our observations, asiatic acid exerts a stronger suppressive effect on TNF-[alpha]-induced endothelial hyperpermeability, compared to asiaticoside
asiatica leaves, namely the glycoside asiaticoside
(AS) (36-44%) and the genins asiatic and madecassic acid (56-64%), assayed by high-performance liquid chromatography (HPLC).
Enhanced production of asiaticoside
from hairy root cultures of Centella asiatica (L.
For example, different studies for isolation of secondary metabolites has been conducted on Artemisia annua for artemisinin , Aspidospermaramiflorum for ramiflorin , Camellia chinensisfor flavones , Capsicum annum for capsaicin [40,38], and Centellaasiatica for asiaticoside
These applications are most likely due to its biologically active constituents of triterpenes namely asiatic acid and asiaticoside
(Inamdar et al.
, another component present in Centella asiatica, showed antipyretic and anti-inflammatory effects in lipopolysaccharide-trested rat .
12) However, asiaticoside
on its own is a very modest antioxidant and not the strongest antioxidant molecule present in centella.
75-fold greater type I pro-collagen induction compared to the known herbal collagen enhancer asiaticoside
at the same treatment concentration (0.