Subsequent cell experiments revealed that due to the deletion, the serried gene -- ASGR1 -- is unable to establish the normal structure and function of the protein called the asialoglycoprotein receptor
This study evaluated the usefulness of asialoglycoprotein receptor
scintigraphy with [sup.
03 mg/kg of recombinant ApoE was able to fully restore the activity of an siRNA formulated in an iLNP; and,aA alternatively, in the same ApoE knockout model, silencing activity was found to be restored by the use of an exogenous GalNAc ligand that targets the iLNP to the asialoglycoprotein receptor
(ASGR) expressed on hepatocytes, with as little as 0.
Using the hepatocyte-specific asialoglycoprotein receptor
and the substance that specifically binds to it (i.
A 3D model for the human hepatic asialoglycoprotein receptor
Earlier research hinted that another cell-surface molecule, the asialoglycoprotein receptor
, is an entry point for Marburg virus.
For example, competition for clearance by the asialoglycoprotein receptor
of the liver between asialylated intestinal ALP and asialoglycoproteins can lead to increased serum concentrations of intestinal ALP (5).
Our patient had tested negative for acute and chronic viral hepatitis as well as asialoglycoprotein receptor