In another experiment, T cells with two complementary CARs against GPC3 and asialoglycoprotein receptor
1 (ASGR1) decreased the risk of on-target, off-tumor toxicities and demonstrated potent antitumor immune responses targeting GPC3+ ASGR1+ HCCs both in vivo and in vitro .
Sia covers penultimate galactose residue that is recognized by an asialoglycoprotein receptor
. In a similar way, Sia covers penultimate LacNAc (Gal[beta]1-4GlcNAc) that is recognized by a [beta] galactoside recognition lectin, it is known as galectin.
Subsequent cell experiments revealed that due to the deletion, the serried gene -- ASGR1 -- is unable to establish the normal structure and function of the protein called the asialoglycoprotein receptor
. The receptor protein binds certain sugars and surprisingly, it now turns out that the receptor plays an important role in our cholesterol metabolism and potentially related to vascular inflammation, and in whether or not we develop arteriosclerosis in coronary arteries.
This study evaluated the usefulness of asialoglycoprotein receptor
scintigraphy with [sup.99m]Tc-galactosyl human serum albumin ([sup.99m]Tc-GSA scintigraphy) as an early predictor for prognosis of acute liver failure.
Group 2 C-Type Lectin Receptors: Asialoglycoprotein Receptor
Mammalian hepatocytes possess large numbers of high-affinity, cell-surface receptors (asialoglycoprotein receptor
, ASGP-R) that can bind asialoglycoproteins [13-15].
The data showed that as little as 0.03 mg/kg of recombinant ApoE was able to fully restore the activity of an siRNA formulated in an iLNP; and,aA alternatively, in the same ApoE knockout model, silencing activity was found to be restored by the use of an exogenous GalNAc ligand that targets the iLNP to the asialoglycoprotein receptor
(ASGR) expressed on hepatocytes, with as little as 0.15 mole% GalNAc ligand being sufficient to give near maximal activity.
Using the hepatocyte-specific asialoglycoprotein receptor
and the substance that specifically binds to it (i.e., ligand), asialooro-somucoid, as a model, we showed that ethanol metabolism not only decreased the binding of the ligand to the receptor but also impaired internalization and degradation of the ligand.
A 3D model for the human hepatic asialoglycoprotein receptor
Earlier research hinted that another cell-surface molecule, the asialoglycoprotein receptor
, is an entry point for Marburg virus.
This impaired tolerance towards a self-receptor molecule may be the onset of a strong humoral and cellular autoaggression, such as reported for the asialoglycoprotein receptor
and its role in autoimmune liver diseases as the only liver-specific autoantigenic target [51, 52].
For example, competition for clearance by the asialoglycoprotein receptor
of the liver between asialylated intestinal ALP and asialoglycoproteins can lead to increased serum concentrations of intestinal ALP (5).