asialoglycoprotein receptor


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a·si·a·lo·gly·co·pro·tein re·cep·tor

a surface receptor found in hepatocytes that binds galactose-terminal glycoproteins; thus, this receptor removes those proteins from circulation and they are in turn acted on by hepatocyte lysosomes.
References in periodicals archive ?
Subsequent cell experiments revealed that due to the deletion, the serried gene -- ASGR1 -- is unable to establish the normal structure and function of the protein called the asialoglycoprotein receptor.
03 mg/kg of recombinant ApoE was able to fully restore the activity of an siRNA formulated in an iLNP; and,aA alternatively, in the same ApoE knockout model, silencing activity was found to be restored by the use of an exogenous GalNAc ligand that targets the iLNP to the asialoglycoprotein receptor (ASGR) expressed on hepatocytes, with as little as 0.
Using the hepatocyte-specific asialoglycoprotein receptor and the substance that specifically binds to it (i.
Earlier research hinted that another cell-surface molecule, the asialoglycoprotein receptor, is an entry point for Marburg virus.
For example, competition for clearance by the asialoglycoprotein receptor of the liver between asialylated intestinal ALP and asialoglycoproteins can lead to increased serum concentrations of intestinal ALP (5).
Our patient had tested negative for acute and chronic viral hepatitis as well as asialoglycoprotein receptor antibodies.

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