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A glycoprotein without a sialic acid moiety; such proteins are recognized by asialoglycoprotein receptors and are targeted for degradation.
Farlex Partner Medical Dictionary © Farlex 2012
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Torchio et al., "Removal systems of immunoglobulin A and immunoglobulin A containing complexes in IgA nephropathy and cirrhosis patients: The role of asialoglycoprotein receptors," Laboratory Investigation, vol.
One study used G5.NH2 dendrimers modified with lactobionic acid (LA), which specifically binds asialoglycoprotein (ASGP), as a scaffold to reduce AuNP.
In another experiment, T cells with two complementary CARs against GPC3 and asialoglycoprotein receptor 1 (ASGR1) decreased the risk of on-target, off-tumor toxicities and demonstrated potent antitumor immune responses targeting GPC3+ ASGR1+ HCCs both in vivo and in vitro [41].
Sia covers penultimate galactose residue that is recognized by an asialoglycoprotein receptor.
Compared to native LDL, desialylated LDL has a higher capacity to bind to asialoglycoprotein receptor, a high capacity C-type lectin receptor, mainly expressed on hepatocytes.
Furthermore, the flexible polysaccharide blocks containing 2-5% galactan have the ability to recognize hepatocytes due to the presence of asialoglycoprotein receptors (ASGPR) on which galactose acts as a specific adhesive ligand on the hepatocytes [15-19] (Figure 2).
NPs containing galactose have been developed to deliver therapeutic agents (chemotherapeutic agents, DNA) to the asialoglycoprotein receptor on liver cells for over 30 years [128, 129].
[51] targeted asialoglycoprotein receptor in hepatocytes using lactobionic acid-functionalized [sup.99m]Tc-DTPA-IONP.
CLR includes the mannose receptor (CD206), primarily present on the surface of macrophages and dendritic cells (DC), and asialoglycoprotein receptor family which includes DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (CD209) and DC-associated C-type lectin-1 (Dectin-1) [5].
During the second stage, from 9th to 14th day, albumin (ALB), ornithine transcarbamylase (TAT) as well as mRNA levels for VII clotting factor, asialoglycoprotein receptor 1 (ASGPR1), and CYP1A2 member of cytochrome P450 superfamily production are increased while AFP levels are reduced [65-68].
Subsequent cell experiments revealed that due to the deletion, the serried gene -- ASGR1 -- is unable to establish the normal structure and function of the protein called the asialoglycoprotein receptor.
Autoantibodies detected in CLDs target a wide repertoire of host antigens, which include proteins from the nucleus, the cytoskeleton, liver kidney microsomes, the mitochondria, and the cytoplasm of neutrophilic granulocytes, as well as liver soluble antigens, asialoglycoprotein receptors, TAA, and stress proteins [21].

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