Among the women with serial Pap smear screening (3 or more) the majority did not progress beyond ASCUS
. No one in this study progressed to HSIL.
studied two approaches to triage women with ASCUS
or LSIL: 1) repeating the cytological test, and 2) DNA testing for high-risk types of the human papillomavirus (hrHPV) - the main causal factor of cervical cancer.
Total cervical smears done in 2007 and 2009, with a breakdown of results Cervical 2007 2009 cytology n (%) n (%) results Unsuitable 10 (1.1) 29 (1.8) Normal 654 (73.8) 1 096 (67.3) Benign changes 48 (5.4) 85 (5.2) Atypia 7 (0.8) 32 (2.0) ASCUS
30 (3.4) 30 (1.8) ASC-H 1 (0.1) 5 (0.3) AGUS 1 (0.1) 3 (0.2) LSILs 93 (10.5) 221 (13.6) HSILs 36 (4.1) 125 (7.7) Malignant 6 (0.7) 2 (0.1) Total 886 (100.0) 1 628 (100.0) ASCUS
= atypical squamous cells of undetermined significance; ASC-H = atypical squamous cells --cannot exclude HSIL; AGUS = atypical glandular cells of undetermined significance; LSILs = low-grade squamous intraepithelial lesions; HSILs = high-grade squamous intraepithelial lesions.
There are two categories of ambiguous pathological lesions, namely ASCUS
(atypical squamous cells of undetermined significance) and AGUS (atypical glandular cells of undetermined significance).
Any Pap report of low-grade squamous intra-epithelial lesions or atypical squamous cells of undetermined significance (ASCUS
) was repeated in 6 months.
The abnormalities detected were ASCUS
(0.48%), ACS-H (0.06%), LSIL (0.19%), HSIL (0.37%), SCC (0.10%), AGUS (0.25%), and adenocarcinoma (0.05%).
Cannonia differs from other Xylariaceae genera by its ascus
features: broad cylindrical to clavate, 8spored, with very short pedicel, inamyloid, lacking apical apparatus, and the ascus
can be evanescent.
These tests have high clinical specificity for detecting disease and may also predict which women with LSIL or atypical squamous cells of unknown significance (ASCUS
) have the potential to progress to cervical cancer (Fig.
Prevalence and typing of HPV DNA by hybrid capture II in women with ASCUS
, ASC-H, LSIL, and AGC on ThinPrep Pap tests.