arylsulfatase


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ar·yl·sul·fa·tase

(ar'il-sŭl'fă-tās),
An enzyme that catalyzes the hydrolysis of phenol sulfates, including cerebroside sulfates (that is, a phenol sulfate + H2O → a phenol + sulfate anion). Some arylsulfatases are inhibited by sulfate (type II) and some are not (type I).
Synonym(s): sulfatase (2)

ar·yl·sul·fa·tase

(ar'il-sŭl'fă-tās)
An enzyme that cleaves phenol sulfates, including cerebroside sulfates (i.e., a phenol sulfate + H2O → a phenol + sulfate anion). Some arylsulfatases are inhibited by sulfate (type II) and some are not (type I).
Synonym(s): sulfatase (2) , arylsulphatase.

arylsulfatase

a group of enzymes active in the hydrolysis of sulfates and the metabolism of mucopolysaccharides; found in liver, pancreas, kidneys and immature monocytes. Several species of molluscs and Aerobacter spp. serve as commercial sources of the enzyme which is used in analytic endocrinology.

arylsulfatase A deficiency
see metachromatic leukodystrophy.
arylsulfatase B deficiency
is the cause of mucopolysaccharidosis VI which occurs in humans and cats. Called also Maroteaux-Lamy syndrome.
References in periodicals archive ?
Soil arylsulfatase activity was determined using acetate buffer and p-nitrophenyl (PNP) sulfate (20 mM) as a substrate (Tabatabai and Bremner 1970).
Identification to species level was achieved on the basis of the growth characteristics, including growth in less than 7 days, growth at 37[degrees]C, growth in the presence of NaCl 5%, pigment production, Niacin production, pyrazinamidase, urease, nitrate reduction test, catalase test, heat-stable catalase (pH 7, 68[degrees]C), Tween 80 hydrolysis, growth on MacConkey agar, arylsulfatase test, and colony morphology.
Activity of some hepatic enzymes in schistosomiasis and concomitant alteration of arylsulfatase B.
Early reports of DPHL suggested an associated deficiency of arylsulfatase A, an enzyme required in the modulation of myelin; however, more recent case reports are conflicting.
Prevalence of anti-adeno-associated virus serotype 8 neutralizing antibodies and arylsulfatase B cross-reactive immunologic material in mucopolysaccharidosis VI patient candidates for a gene therapy trial.
Moreover, the 3 genomes we identified contain homologs of arylsulfatase and genes that enable invasion of brain endothelial cells, which contribute to the ability of Escherichia coli to cross the blood-brain barrier in neonatal meningitis (32).
In a study of MPS-VI using DBS, all 7 MPS-VI patients displayed arylsulfatase B protein and activity after immunocapture below the values for 32 controls (53).
Urease, L-glutaminase, L-asparaginase, alkaline phosphomonoesterase, and arylsulfatase activities were determined in the rhizospheric soil according to the protocols described by Tabatabai [16, 17].
For example, the M fortuitum and M chelonae/M abscessus groups are strongly positive for the arylsulfatase reaction at 3 days, in contrast to Mycobacterium wolinskyi and the M smegmatis group.
DSM's patent application for Maxilact[R] lactase, which is free from arylsulfatase, has been granted in Europe.
Enzyme replacement therapy for mucopolysaccharidosis VI: a phase 3, randomized, double-blind, placebo-controlled, multinational study of recombinant human N-acetylgalactosamine 4-sulfatase (recombinant human arylsulfatase B or rhASB) and follow-on, open-label extension study.