ARNTL

(redirected from aryl hydrocarbon receptor nuclear translocator-like)

ARNTL

A gene on chromosome 11q15 that encodes a basic helix-loop-helix protein which forms a heterodimer with CLOCK and binds an E-box upstream of PER1, activating it and possibly other circadian-rhythm-associated genes.
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We recently reported that BNP mRNA contents, but not ANP mRNA contents, are produced in a circadian manner in the ventricles of wild-type mice and that the production pattern reflects the local expression of the central clock genes Perl [period homolog 1(Drosophila)] and Bmall [officially known as Arntl (aryl hydrocarbon receptor nuclear translocator-like)] (2).
AhR/ARNT and the clock proteins (circadian locomotor ourpur cycles kaput; CLOCK) and BMAL1 [brain, muscle ARNT-like protein 1; also called Arntl (aryl hydrocarbon receptor nuclear translocator-like)] share structural similarities and exhibit diurnal changes in multiple tissues (Richardson et al.