aryl hydrocarbon hydroxylase


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aryl hydrocarbon hydroxylase (AHH)

an enzyme that converts carcinogenic chemicals in tobacco smoke and in polluted air into active carcinogens within the lungs. Aryl hydrocarbon hydroxylase is the subject of numerous studies to determine why cancer develops in some smokers but not in others. Experimental blood tests indicate that the level of aryl hydrocarbon hydroxylase may be a factor in hereditary predisposition of a cigarette smoker to cancer.
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Maternal cigarette smoking, placental aryl hydrocarbon hydroxylase and neonatal size.
Aryl hydrocarbon hydroxylase activity in human placenta of passive smokers.
As a consequence of this variability, aryl hydrocarbon hydroxylase (encoded by the CYP1A1 gene) and glutathione-S-transferase (encoded by the GSTT1 gene) work either more or less effectively at clearing toxicant intermediates, depending on the individual.
Octachloronaphthalene induction of hepatic microsomal aryl hydrocarbon hydroxylase activity in the immature male rat.

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