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assisted reproductive technology
ARTAnturane Reinfarction Trial. A clinical trial comparing sulfinpyrazone to placebo in the first month post acute myocardial infarction; the sponsors trumpeted its alleged cardiovascular benefits—a 32% reduction in cardiac mortality rate, almost entirely due to a reduction in sudden death in the first 6 months, which occurred because the drug sponsor carved a subgroup out of the data set.
Per the FDA, "We are aware that it is unusual for an FDA critique of a clinical trial to be published in the medical literature. We believe that it is important in this instance, however, because … it illustrates so clearly the problems that may arise from subgroup analyses and exclusion of patients from analysis after they have completed a study … Our review … indicates that the cause-of-death classification and all conclusions based on it are unreliable, and that the favorable effect of sulfinpyrazone on overall mortality, especially during the first six months, depends heavily on the after-the-fact exclusion of certain deaths from the analysis”.
1. Antiretroviral therapy, see there.
2. Assisted reproductive technology, see there.
Abbreviation for acoustic reflex threshold.