artificial liver


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An extracorporeal supportive device for a person with acute liver failure. Bioartificial livers are not intended as permanent replacements, but as stop-gaps while one is awaiting liver transplantation. The current generation devices contain hepatocytes embedded in a gel. The patient’s plasma is removed and circulated through the device and returned, minus the metabolic wastes produced by the body which are normally removed by a healthy liver

artificial liver

Biotech A cartridge with cloned human liver cells, through which blood flows to facilitate removal of waste products. See Extracorporeal liver assist device, Liver dialysis.

artificial liver

A biomechanical device typically combining a system of filters to remove toxins from the blood with hepatic cells or tissue. It is designed to support patients with hepatic failure temporarily until a donor liver becomes available for transplantation.
See also: liver

artificial liver

An as yet unrealized entity that is, nevertheless, the subject of promising research and development. Current ambitions are to produce extracorporeal devices that will enable patients with liver failure to be kept alive until regeneration of transplantation is achieved. The principal difficulty arises from the large number of different metabolic functions performed by the liver. A promising approach is the use of cloned human liver cells grown around numerous fine semipermeable tubules through which the patient's blood is passed.
References in periodicals archive ?
[2] Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association, Severe Liver Diseasesand Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association, "Guidelines for diagnosis and treatment liver failure," Chinese Journal of Infectious Diseases, vol.
Ryska, "Artificial liver support system reduces intracranial pressure more effectively than bioartificial system: an experimental study," International Journal of Artificial Organs, vol.
Artificial livers are still in development, but Talbot pointed out other applications for PICM-19 cells.
"This is a significant achievement that marks a major milestone in the development of our artificial liver device.
Joseph Vacanti has spent more than 20 years working toward an artificial liver, experimenting with various types of support structures that might allow specialized cells such as hepatocytes (liver cells) to grow and function outside an actual organ.
In November last year, Prof McGuckin and his team used stem cells taken from umbilical cords to grow a tiny artificial liver, believed to be the first of its kind in the world, which could potentially eradicate the need to test drugs on humans and animals.
SCIENTISTS have grown an artificial liver that is set to revolutionise the medical world, it was revealed yesterday.
Scientists at Newcastle University have used the technique to create an artificial liver to be tested, which could eventually be developed to transplant into humans.
Successful research outcomes will result in the incorporation of the PICM-19H cells in an artificial liver device for use by patients suffering from chronic and acute liver disease, as well as use in in-vitro toxicology and pre-clinical drug testing platforms.
Artificial liver system developers include Vancouver-based HepaLife.

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