artificial liver


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An extracorporeal supportive device for a person with acute liver failure. Bioartificial livers are not intended as permanent replacements, but as stop-gaps while one is awaiting liver transplantation. The current generation devices contain hepatocytes embedded in a gel. The patient’s plasma is removed and circulated through the device and returned, minus the metabolic wastes produced by the body which are normally removed by a healthy liver

artificial liver

Biotech A cartridge with cloned human liver cells, through which blood flows to facilitate removal of waste products. See Extracorporeal liver assist device, Liver dialysis.

artificial liver

A biomechanical device typically combining a system of filters to remove toxins from the blood with hepatic cells or tissue. It is designed to support patients with hepatic failure temporarily until a donor liver becomes available for transplantation.
See also: liver

artificial liver

An as yet unrealized entity that is, nevertheless, the subject of promising research and development. Current ambitions are to produce extracorporeal devices that will enable patients with liver failure to be kept alive until regeneration of transplantation is achieved. The principal difficulty arises from the large number of different metabolic functions performed by the liver. A promising approach is the use of cloned human liver cells grown around numerous fine semipermeable tubules through which the patient's blood is passed.
References in periodicals archive ?
PharmaCytes therapy essentially moves the normal conversion site of that inactive drug (the patients liver) closer to the cancerous tumor by using Cell-in-a-Box capsules and the live cells inside them to do the job of the patients liver or to act as an artificial liver.
Artificial liver support systems in the management of complications of cirrhosis.
According to researchers, the most vital component in an artificial liver device is not the mechanical hardware, but rather, it is the biological cells inside the device which are responsible for truly replicating and performing the functions of the human liver, similar to the functions mimicked by HepaLife's PICM-19 cells in today's research outcomes.
It is the vital first step in creating a fully artificial liver that can be used for transplants.
And it is the first step in creating a fully artificial liver that can be used for transplants.
Moreover, the ability to place these cells in 'suspended animation' at room temperature will enable more efficient utilization of HepaLife's artificial liver device in its clinic or hospital setting.
Committee head Hiroshi Saito, dean of the school, said the panel gave the green light to the plan to prepare for the test using an artificial liver for treatment of acute liver failure after closed-door deliberations.
Sugimachi had planned to temporarily utilize the artificial liver externally before human organ transplants or during rehabilitation for patients suffering from fulminant hepatitis.
and to lease the camera to an artificial liver support.
Dubai: By highlighting the experience of a group of Emirati inventors in the medical sector, such as the inventor of the artificial liver, the Mohammad Bin Rashid Centre for Government Innovation (MBRCGI) emphasised the importance of developing medical practices through innovation at the aACAyFuture of Innovation in the Health Sector' session.
They believe that these cells called PICM-19 could make artificial liver devices more effective.