arthrogryposis multiplex congenita
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ar·thro·gry·po·sis mul·'ti·plex con·gen·'i·ta[MIM*108110]
limitation of range of joint motion and contractures present at birth, usually involving multiple joints; a syndrome probably of diverse etiology that may result from changes in spinal cord, muscle, or connective tissue. Several forms exist, autosomal dominant [MIM*108110, 108120, 108130, 108140, 108145, 108200], recessive [MIM*208080, 208081, 208085, 208100, 208150, 208155, 208200], and X-linked [MIM*301830]
Synonym(s): amyoplasia congenita
Farlex Partner Medical Dictionary © Farlex 2012
arthrogryposis multiplex congenitaA rare sporadic condition characterised by joint contractures, dislocations, rigid skeletal deformities (e.g., clubfoot or talipes equinovarus), skin atrophy and replacement of limb muscles with fibrous tissue. AMC is not a sui generis disease, but rather a descriptive term that signifies multiple congenital contractures. The aetiologies encompass both neurogenic and primary myopathic diseases, but most cases are not due to neuromuscular disease.
Uncertain; a common link may be intrauterine movement during a critical period of limb development.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
ar·thro·gry·po·sis mul·ti·plex con·gen·i·ta(ahr'thrō-gri-pō'sis mŭl'ti-pleks kon-jen'i-tă)
Limitation of range of joint motion and contractures present at birth, usually involving multiple joints; a syndrome probably of diverse etiology that may result from changes in spinal cord, muscle, or connective tissue.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012