arthrogryposis


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arthrogryposis

 [ahr″thro-grĭ-po´sis]
1. persistent flexion of a joint.
2. tetanoid spasm.

ar·thro·gry·po·sis

(ar'thrō-gri-pō'sis),
Congenital defect of the limbs characterized by severe contractures of multiple joints.
[arthro- + G. gryphōsis, a crooking]

arthrogryposis

/ar·thro·gry·po·sis/ (ahr″thro-grĭ-po´sis) persistent flexure of a joint.

arthrogryposis

(är′thrə-grə-pō′sĭs)
n. pl. arthrogrypo·ses (-sēz)
The permanent fixation of a joint in a contracted position.

arthrogryposis multiplex congenita

A rare sporadic condition characterised by joint contractures, dislocations, rigid skeletal deformities (e.g., clubfoot or talipes equinovarus), skin atrophy and replacement of limb muscles with fibrous tissue. AMC is not a sui generis disease, but rather a descriptive term that signifies multiple congenital contractures. The aetiologies encompass both neurogenic and primary myopathic diseases, but most cases are not due to neuromuscular disease.
 
Pathogenesis
Uncertain; a common link may be intrauterine movement during a critical period of limb development.
 
Management
Arthrodesis.

ar·thro·gry·po·sis

(ahr'thrō-gri-pō'sis)
Congenital defect of the limbs characterized by contractures of multiple joints.
[arthro- + G.gryphōsis, a crooking]

arthrogryposis

Congenital fixation of the limb joints, usually in an extended position. The condition is probably due to a destructive disorder of the motor nerves to the muscles around the affected joints during the pregnancy.

arthrogryposis

1. persistent flexion of a joint.
2. tetanoid spasm.

congenital arthrogryposis with dysraphism
arthrogryposis with delayed or arrested closure of the neural tube. Called also arthrogryposis multiplex congenita. See also complex vertebral malformation.
arthrogryposis and hydranencephaly
see akabane virus disease.
inherited arthrogryposis
occurs in catle, pigs and sheep. In cattle it is commonly associated with cleft palate, sometimes with other skeletal defects and also prolonged gestation.
lupine-induced arthrogryposis
occurs in calves whose dams have ingested Lupinus spp. that contain the teratogenic alkaloids anagyrine and/or ammodendrine between 35 and 100 days gestation. These alkaloids impair the natural active movement of the developing fetus so that it grows in a static state resulting in deformities of the limbs. Many western lupine species, bitter lupines, contain these teratogenic alkaloids but they are usually not palatable and not eaten. The alkaloid conine in Conium maculatum can also produce this syndrome.
arthrogryposis multiplex congenita
see congenital arthrogryposis with dysraphism (above).
References in periodicals archive ?
A) Neonate 1: typical microcephaly phenotype; arthrogryposis in upper and lower limbs.
The findings in 6 of the cases of fetal malformations, which included variable findings of limb malformations and arthrogryposis with multiple congenital contractures, craniofacial malformations, craniosynostosis, intrauterine growth restriction, and pulmonary hypoplasia, are likely not due to the direct cytopathic effects of the Zika virus.
The children had a broad range of neuromuscular diagnoses: arthrogryposis (14), cerebral palsy (3), spinal muscular atrophy (2), muscular dystrophy (2), and "other" (4).
One infant with arthrogryposis was difficult to assess because of increased tone in some muscles and decreased in others.
Arthrogryposis Multiplex Congenita (AMC) is a disorder with multiple aetiological factors.
ZIKV infection in pregnant women become a matter of concern, because the explosive increase in the incidence of fetal and neonatal Central Nervous System (CNS) abnormalities, such as microcephaly, cerebral calcifications, ventriculomegaly, cerebral destruction lesions, hydrops fetalis, arthrogryposis, detected in association with ZIKV infection.
Amir is the only person in Nepal known to suffer from arthrogryposis multiplex congenita.
We also meet Zoe, who has arthrogryposis, a condition that affects movement in her limbs.
Spectrum of mutations that cause distal arthrogryposis types 1 and 2B.
Zoe's headmistress wants her to try out for head girl, but she's started to feel self-conscious about her arthrogryposis.
Jackie Williams said her niece Tanika, 10, from Belle Vale, had said she "didn't want to be here any more" because of her condition, called arthrogryposis.

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