Laboratory studies have demonstrated that platelets exert arthritogenic
properties through the activation of the collagen glycoprotein VI receptor and subsequent shedding of microparticles.
Mxra8 is a receptor for multiple arthritogenic
Alphaviruses having single-stranded RNA genome belong to Togaviridae family of viruses and are divided into arthritogenic
viruses (old world) and encephalitogenic viruses (new world) including equine encephalitis viruses.
Lopez de Castro, "HLA-B27 presents a peptide from a polymorphic region of its own molecule with homology to proteins from arthritogenic
bacteria," Tissue Antigens, vol.
potential of Th17 cells is mainly due to the pleiotropic effects of IL-17A (IL-17), which is produced by Th17 cells and acts on a variety of cells that constitute the synovial tissue [14, 15].
These include presentation of an arthritogenic
peptide of Yersinia and Chlamydia by particular HLA-B27 alleles8, aberrant/ misfolded expression of HLA-B27 heavy chains and enhanced intracellular microbial survival9.
Persistent chronic inflammation and infection by Chikungunya arthritogenic
alphavirus in spite of a robust host immune response.
alphaviruses: new insights into arthritis and bone pathology.
alphaviruses--an overview," Nature Reviews Rheumatology, vol.
Invasion of endothelial cells and arthritogenic
potential of endocarditis-associated Corynebacterium diphtheria.
Adjuvant oil induces waves of arthritogenic
lymph node cells prior to arthritis onset.
They address genome structure and replication, laboratory diagnosis and detection, interaction with the interferon system, antiviral responses in mosquitoes, animal models of alphavirus-induced inflammatory disease, clinical manifestations of arthritogenic
alphaviruses, encephalitic alphaviruses, the application of alphaviruses for gene therapy, and chikungunya virus pathogenesis and the development of control strategies.