Laboratory studies have demonstrated that platelets exert arthritogenic
properties through the activation of the collagen glycoprotein VI receptor and subsequent shedding of microparticles.
Alphaviruses having single-stranded RNA genome belong to Togaviridae family of viruses and are divided into arthritogenic
viruses (old world) and encephalitogenic viruses (new world) including equine encephalitis viruses.
Lopez de Castro, "HLA-B27 presents a peptide from a polymorphic region of its own molecule with homology to proteins from arthritogenic
bacteria," Tissue Antigens, vol.
potential of Th17 cells is mainly due to the pleiotropic effects of IL-17A (IL-17), which is produced by Th17 cells and acts on a variety of cells that constitute the synovial tissue [14, 15].
These include presentation of an arthritogenic
peptide of Yersinia and Chlamydia by particular HLA-B27 alleles8, aberrant/ misfolded expression of HLA-B27 heavy chains and enhanced intracellular microbial survival9.
Persistent chronic inflammation and infection by Chikungunya arthritogenic
alphavirus in spite of a robust host immune response.
alphaviruses: new insights into arthritis and bone pathology.
alphaviruses--an overview," Nature Reviews Rheumatology, vol.
Invasion of endothelial cells and arthritogenic
potential of endocarditis-associated Corynebacterium diphtheria.
They address genome structure and replication, laboratory diagnosis and detection, interaction with the interferon system, antiviral responses in mosquitoes, animal models of alphavirus-induced inflammatory disease, clinical manifestations of arthritogenic
alphaviruses, encephalitic alphaviruses, the application of alphaviruses for gene therapy, and chikungunya virus pathogenesis and the development of control strategies.