Diversity and evolution of a newly emerged North American Type 1 porcine arterivirus
: Analysis of isolates collected between 1999 and 2004.
Wills et al., "Discovery of a small arterivirus gene that overlaps the gp5 coding sequence and is important for virus production," Journal of General Virology, vol.
Meulenberg, "Kissing interaction between 31 noncoding and coding sequences is essential for Porcine arterivirus RNA replication," Journal of Virology, vol.
La enfermedad es causada por un virus ARN de cadena sencilla, perteneciente al orden Nidovirales, familia Arteriviridae, genero Arterivirus
, grupo Nidovirus .
La enfermedad es producida por un virus del genero Arterivirus
, referido como ATTC-2332 cadena de virus en Norteamerica y como virus de Lelystad en Europa .
Open reading frame 1a--encoded subunits of the arterivirus
replicase induce endoplasmic reticulum-derived double-membrane vesicles which carry the viral replication complex.
In North America and Europe, the syndrome is caused by two genotypes of porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus whose genomes diverge by approximately 40%.
Although the N-protein is a relatively conserved arterivirus protein, considerable amino acid differences exist between European and North American PRRSVs.
Polylactosaminoglycan chains on the ectodomain of the primary envelope glycoprotein of an arterivirus determine its neuropathogenicity, sensitivity to antibody neutralization and immunogenicity of the neutralization epitope.