Biopsy revealed hyperkeratosis and irregular acanthosis of epidermis, homogenous eosinophilic hyaline material deposition in arteriocapillary
wall, adnexal basement region, sweat coils & dermis Fig.4.
Hemoglobin in arteries (invasive, aHb) and capillaries (non-invasive, SpHb) are used to calculate the arterial and capillary plasma dilution efficacies (aPDE and cPDE, respectively) and arteriocapillary
plasmadilution efficacy difference (acPED) , .
More specifically, the stepwise fluid loading has to be stopped when invasively and noninvasively measured capillary plasma dilution efficacy of a fluid challenge is minimized and arteriocapillary
plasma dilution efficacy difference becomes negative .