artemisinin


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ar·te·mis·i·nin

(ar'te-mis'in-in),
A sesquiterpene antimalarial and antischistosomal drug derived from Artemisia annua; a. is a potent and rapidly acting blood schizontocide used in the treatment of malaria; active against chloroquine-resistant Plasmodium falciparum and chloroquine-sensitive P. falciparum and P. vivax.

artemisinin

(är′tə-mĭs′ĭ-nĭn)
n.
1. A compound, C15H22O5, that is obtained from a species of artemisia (Artemisia annua) and has antimalarial activity.
2. Any of several semisynthetic derivatives of this compound that are used to treat malaria, usually in combination with other drugs.

artemisinin

An antimalarial drug derived from Artemisia annua . The drug is claimed to be effective in treating cerebral malaria and is active against chloroquine-resistant P. falciparum and chloroquine-sensitive P. falciparum and P. vivax . The drug is a traditional Chinese remedy. See also QUINGHAO.
References in periodicals archive ?
Around the turn of the century, Novartis introduced Coartem, the first combination therapy antimalarial using artemisinin (known as artemisinin combination therapy, or ACT) (WHO 2002).
The structural biologist was the first to solve the crystal structures of two different artemisinin derivatives artesunate and artemether in a complex with gephyrin.
Keywords: artemisinin, artemether and coartem, toxic effect, histological changes, ALT, AST.
At earlier time, in July 2018, Chongqing Pharmaceutical Research Institute Co., Ltd ("CPRI"), the Research and Development platform of Fosun Pharma, was awarded with 450,000 USD from the Bill & Melinda Gates Foundation ("Gates Foundation"), a non-profit organization, for the development of a semi-synthetic Artemisinin manufacturing process.
Therefore, preexisting pfpm2 duplications in Cambodia might have been rapidly selected by DHA/PPQ, aided by a less effective protective action of the artemisinin derivative (7).
Currently, artemisinin is extracted from the sweet wormwood plant, which takes around eight-months to mature and yields about 15 grams of artemisinin for every kilogram of plant, added the company.
Sriwichai et al., "Artemisinin resistance in Cambodia: A clinical trial designed to address an emerging problem in Southeast Asia," Clinical Infectious Diseases, vol.
Because of artemisinins' rapid elimination, they are used in combination with an agent that also kills blood parasites but has a slower elimination rate and a different mechanism of action.
The third cluster (blue) focuses on artemisinin related resistance and its geographical distribution in Asia and Africa.
Another reason is that production of artemisinin derivatives that meets toxicity and Good Manufacturing Practices (GMP) standards is limited (Haynes, 2001 and Malomo et al., 2001; Adebayo and Malomo, 2002; Borstnik et al., 2002; Afonso et al., 2006; Boareto et al., 2008).
In addition to their antimalarial activity, artemisinin from Artemisia annua L.
Preliminary evidence suggests that proteasome inhibitors, a class of drugs currently used as anticancer agents, might have the potential to restore the effectiveness of the world's leading malaria drug, artemisinin, and its derivatives.