Phytochemsitry of Artemisia annua and the development of Artemisinin
derived antimalarial agents, Chap.
is currently extracted from sweet wormwood (Artemisia annua) at high cost.
Likewise, the interaction between hemin and artemisinin
, in the presence of hemin in a large number of malaria parasites cause hemoglobin digestion (11) and it need prevention of parasitemia in hemoglobin.
The WHO opposes the use of artemisinin
on its own because of evidence from Asia that parasites are becoming resistant to it, yet about half of all African countries still permit the application of artemisinin
as a monotherapy.
Amyris, a California-based biotech company, has developed a way to get yeast to pump out artemisinic acid, the precursor to artemisinin
, rather than extracting it from the sweet wormwood plant (Nature, doi.
Plants have always formed a useful source for new anti-malarial drugs (quinine and artemisinin
being two of the most notable examples).
But if poor-quality drugs build malaria's resistance to artemisinin
, the consequences would be grave.
derivatives, such as artesunate, are combined with older drugs which on their own have ceased to be effective.
the technology transfer arm of the University, introduces a novel method allowing artemisinin
production in a heterologous (that is, other than A.
Clinical trials conducted by TDR (Training and research in tropical Diseases, Geneva), as early as 2003 have proved the efficacy and superiority of Artemisinin
combination therapy (ACT) for chloroquine resistant malaria .
The use of oral Artemisinin
based monotherapies threatens the therapeutic life of ACTs by fostering the spread of resistance to artemisinins
IT'S seen as a key component in many anti-malaria drugs, but the challenge of managing Artemisinin
is more complicated than just sticking it on a list and picking it up from the shops.