Although cigarettes are known to kill millions of people every year, Professor Alexander Vainstein and his research team at the Hebrew University of Jerusalem have found that tobacco plant can be altered to produce "artemisin," an active component in malaria treatment, according to Israel's 21C news site.
The natural compound artemisin comes from the sweet wormwood plant and can fight drug-resistant malaria, but due to its small quantities and high price, millions of people cannot get access to this remedy.
However, Vainstein and his colleagues spliced the wormwood enzymes that produce artemisin and bred tobacco plants that carry artemisin's genetical code, English.news.cn.
(60) For example the story of Artemisin
, a traditional herbal remedy in Chinese medicine, has proven value as an antimalarial, particularly in combination with other drugs.
The WHO publication, Guidelines on Cultivating Essential Plants Used in Anti-Malaria Medicines describes in detail how to grow Artemisia Annua and importantly, how to plan production of its essential products and extract artemisin
from the dried leaves.
Alkylation of human albumin by the antimalarial artemisin
. Biochem Pharmacol 1993; 46:336-9.
vivax olgularinda artemeter+ lumefantrine, artesunate+mefloquine, artesunate+amodiaquine gibi artemisin
bazli kombinasyon tedavileri oncelikle onerilmektedir (1, 2, 11).
Besides the flavonoide p7F, artemisin
and its metabolite artesunate present in wormwood, though in very small amounts, may also have played a role in the observed effect of this herb.
Periferik yaymasinda yuzuk formasyonu gorulmesi uzerine ilk gun artemisin intravenoz verilirken daha sonra idame olarak artemeter/lumefantrin devam edildi.
Tedavi bilgisi iceren calismalarda 14 P.falciparum sitmasi olgusundan yedisinde artemisin, kalan altisinda kinin iceren tedavi verildigi bildirilmektedir (5, 9-11).
Close collaboration between the pharmaceutical sector, WHO, and the Chinese government resulted in the development of the antimalarial drug artemisin