arsenic intoxication

arsenic poisoning

Toxicity caused by arsenic, a toxic trace metal that is a key component of herbicides, insecticides, rodenticides, wood preservatives and used in manufacturing glass and paints. The usual fatal dose is 100–200 mg; there are ± 1900 arsenic poisonings/year (US), 85% of which are accidental by children < age 6; the rest are adult suicides.
 
Clinical findings
Vague gastrointestinal (nausea, vomiting) and neurologic (apprehension and shortness of breath) symptoms, and a classic sign—“garlic” breath—followed by dysphagia, tachycardia, severe abdominal pain and bloody diarrhoea, then by renal and cardiac failure and circulatory collapse.
 
Treatment
Dimercaprol (BALS).

arsenic intoxication

Arsenic poisoning A toxic trace metal that is a key component of herbicides, insecticides, rodenticides, wood preservatives, and used in manufacturing glass, and paints; the usual fatal dose is 100–200 mg; there are ± 1900 arsenic intoxications/yr–US, 85% of which are accidental by children < age 6; the rest are adult suicides Clinical Vague GI–N&V and neurologic–apprehension and SOB symptoms, and a classic sign, 'garlic' breath, followed by dysphagia, tachycardia, severe abdominal pain and bloody diarrhea, then by renal and cardiac failure and circulatory collapse Treatment Dimercaprol–BAL. See Heavy metals.
References in periodicals archive ?
Urine samples are more valid for the diagnosis of arsenic intoxication, but these too are influenced and often rise dramatically after a seafood meal.
Chronic oral arsenic intoxication as a possible aetiological factor in idiopathic portal hypertension (non-cirrhotic portal fibrosis) in India.
Arsenicosis patients in Guizhou show significantly lower MT transcript levels in blood, which may have predisposed this population to arsenic intoxication.
Adult patients were from an area of endemic arsenic intoxication in Guizhou province (Liu et al.
1981) suggested a neurotoxic potential of arsenic after acute arsenic intoxication of human patients that caused a polyneuropathy with prolonged sensory and motor deficits.
Our group has also reported beneficial effects of vitamins supplementation during arsenic intoxication (95).
147,209,210) A study evaluating chronic arsenic intoxication (100 ppm in water for 12 wk) in rats evaluated the ability of NAC and a chelating agent, DMSA, to preserve hepatic and brain glutathione levels and to normalize erythrocyte enzyme levels.
Replacement of heavily arsenic-contaminated drinking water with low-arsenic water is a potential intervention strategy for arsenosis, although the reversibility of arsenic intoxication has not established.
Therefore, in this follow-up study, we evaluated the impact of intake reduction on chronic arsenic intoxication by investigating urinary excretion of cGMP and peripheral vascular function in arsenosis patients before and after they were supplied with low-arsenic drinking water.
Diagnosis of arsenic intoxication is often difficult because clinical presentation varies depending on route of exposure, chemical form, dose, and time elapsed since exposure.
Because of the natural distribution, drinking water is the most common source of arsenic exposure for the general population (Gebel 2000), and millions of people worldwide suffer from arsenic intoxication caused by drinking arsenic-contaminated water (National Research Council 2001).
In this article we briefly describe chronic arsenic intoxication in Guizhou, China, where burning high-arsenic coal in unventilated stoves is a common practice for heating and drying various foods.