As we enter the second half of the year, we believe we are well positioned to deliver value across our entire portfolio of clinical-stage product candidates, including reporting topline data for the Ovaprene postcoital test clinical trial and initiating the Phase 3 study for DARE-BV1 in the fourth quarter of 2019, and continuing to advance the Sildenafil Cream, 3.6% program for Female Sexual
Arousal Disorder."
She says the rare condition, Persistent Genital
Arousal Disorder (PGAD), has turned her into a recluse.
She has rare persistent genital
arousal disorder, which was apparently sparked by a botched routine smear test.
HSDD can be either generalized (not limited to certain stimulation, situations, or partners) or situational, and can be either acquired (develops only after a period of normal functioning) or lifelong." (5) However, in the most recent APA Diagnostic and Statistical Manual of Mental Health Disorders (DSM-5) iteration, published in 2013, HSDD was merged with female sexual
arousal disorder (FSAD) to form a new diagnostic category of female sexual interest/arousal disorder (FSI/AD), in light of a perceived significant overlap between sexual arousal and desire.
In the DMS-5, the classification of women's sexual problems is now placed into three areas: 1) female sexual interest/
arousal disorder, 2) genito-pelvic pain/penetration disorder, and 3) orgasmic disorder (APA, 2013).
Among the six domains of sexual function, desire disorder (72.0%), and
arousal disorder (52.0%) are the most frequently reported symptoms in this study.
Women's endorsement of different models of sexual functioning supports polythetic criteria of female sexual Interest/
Arousal disorder in DSM-5.
The influencing factors might be physiological, psychological, negative experiences in relationships, low levels of happiness and overall well-being, emotional distress, sexual desire disorders, sexual
arousal disorder, orgasmic disorder, sexual pain disorders, beliefs, past and present experiences/relationships, lifestyle, and other mood disorders (2-32).
Cardiovascular diseases may contribute to
arousal disorder as a result of atherosclerosis of the vessels supplying the vagina and clitoris.
The women had to score lower than 26 on the Female Sexual Function Index (FSFI) and lower than 11 on the Female Sexual Distress Scale (FSDS) and demonstrate one more of the following female sexual dysfunction (FSD) issues: hypoactive sexual desire disorder (HSDD), female sexual
arousal disorder (FSAD), female orgasmic disorder (FOD), or combined genital and subjective
arousal disorder.
Efficacy and safety of sildenafil citrate in women with sexual dysfunction associated with female sexual
arousal disorder. J Women's Health Gend Based Med 2002; 11:367-377.
When both groups are compared in terms of specific domains, the desire and
arousal disorder rates were observed to be higher for patients with AGA.
