clock

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clock

(klŏk)
n.
1. An instrument other than a watch for measuring or indicating time, especially a mechanical or electronic device having a numbered dial and moving hands or a digital display.
2. A biological clock.
v. clocked, clocking, clocks
v.tr.
To register or record with a mechanical device: clocked the winds at 60 miles per hour.

clock′er n.

CLOCK

A gene on chromosome 4q12 that encodes a ubiquitously expressed human homolog of the mouse clock gene, which forms a heterodimer with ARNTL and activates E-box element transcription of several circadian clock proteins (e.g., PER1 and PER2). CLOCK is highly expressed in the suprachiasmatic nucleus.

Molecular pathology
CLOCK-ARNTL double mutations in the PAS domains result in syngernistic desensitisation to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1, disrupting circadian rhythmicity.

clock

(klok)
A device for measuring time.

biological clock

1. An internal system in organisms that influences behavior in a rhythmic manner. Functions such as growth, feeding, secretion of hormones, the rate of drug action, the wake-sleep cycle, the menstrual cycle, and reproduction coincide with certain external events such as day and night, the tides, and the seasons. Biological clocks appear to be set by environmental conditions in some animals, but if these animals are isolated from their environment they continue to function according to the usual rhythm. A gradual change in environment does produce a gradual change in the timing of the biological clock. See: circadian; maladaptation to night work; zeitgeber
2. A colloquial term for the decrease in fertility that accompanies aging, particularly as women approach the age of 35.

Patient discussion about clock

Q. How do you wake up in the morning if your narcolepsy is so severe you can't hear the alarm clock, phone ring? biggest problem is sleep paralysis, can't wake up. Late for work, everything, life is suffering because of severity. Have tried ritalin, natural supplements, hypnosis therapy, Provigal, antidepressants, nothing seems to work. Employer thinks it's an excuse, friends are irritated, I'm at my wits end. Life is spent sleeping more than awake.

A. Narcolepsy cannot yet be cured. But EDS and cataplexy, the most disabling symptoms of the disorder, can be controlled in most patients with drug treatment. Often the treatment regimen is modified as symptoms change. For decades, doctors have used central nervous system stimulants-amphetamines such as methylphenidate, dextroamphetamine, methamphetamine, and pemoline-to alleviate EDS and reduce the incidence of sleep attacks. For most patients these medications are generally quite effective at reducing daytime drowsiness and improving levels of alertness. However, they are associated with a wide array of undesirable side effects so their use must be carefully monitored. Common side effects include irritability and nervousness, shakiness, disturbances in heart rhythm, stomach upset, nighttime sleep disruption, and anorexia. For full article: http://www.ninds.nih.gov/disorders/narcolepsy/detail_narcolepsy.htm#120393201 Hope this helps.

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References in periodicals archive ?
"She is always the person who will give me the honest truth and I appreciate that because in this industry you always get, 'Wonderful dahling' and you never get a straight answer." Rock Around The Clock is touring the country until September.
Because an entangled whale could drown if the researchers didn't pull it to the surface soon enough, team members on shore take shifts around the clock watching the inflatable white buoys on top of the net.
"As New Orleans Mayor Ray Nagin pleaded on national television for firefighters--his own are exhausted after working around the clock for a week--a battalion of highly trained men and women sat idle Sunday in a muggy Sheraton Hotel conference room in Atlanta," reported the September 6 Salt Lake Tribune.
We drove virtually around the clock to reach our forward contact only to find ourselves sitting idle on I-10 in downtown New Orleans.
The machine spun around the clock in the house we shared with four of Meghann's teammates, and our living room decor was dominated by a rotating display of soccer gear drying in front of the space heater.
With the war on terrorism and the demand for more, better-made vehicles, the employees at this depot work around the clock to meet the demands of commanders in theater.
Students and their parents were invited to Read Around the Clock at Brandon, Florida's Randall Middle School recently, the Tampa Tribune reports.
It consists of hundreds of one- to three-credit CPE courses, available around the clock. Authored by leading authorities, courses offer expert guidance on a wide variety of topics, including accounting, auditing, consulting, management and taxation.
His father and the other scientists are working around the clock, and all Stephen knows is that their work has to do with "something that could win the war.
Iberomoldes, a Portuguese mold maker, and Centimfe, a Portuguese moldmaking technology center, are establishing a global network of product and tool designers that can move development of a CAD design continuously from shop to shop in different time zones to keep a project going around the clock.
For three days, rescuers worked around the clock to save nine miners who were trapped 240 feet underground, in Pennsylvania's Quecreek Mine.
And people were working around the clock to try to understand what we were seeing.