aromatase inhibitor


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

aromatase inhibitor

n. Abbr. AI
Any of several drugs that affect the levels of steroids in the blood by inhibiting the enzyme aromatase. Aromatase inhibitors are used especially to lower estrogen levels to control the growth or prevent the recurrence of estrogen-sensitive tumors in post-menopausal women with breast cancer.

aromatase inhibitor

Any of a class of drugs that block the synthesis of estrogen in the body. A number of these agents have been developed to treat breast cancer, which is often a hormone-responsive malignancy.
See also: inhibitor
References in periodicals archive ?
The aromatase inhibitors are the new expansion in the hormonal treatment of breast cancer.
Toxicity of the aromatase inhibitor letrozole to Japanese medaka (Oryzias latipes) eggs, larvae and breeding adults.
Comparision of two aromatase inhibitors in women with Clomiphene resistant polycystic ovary syndrome.
[9.] Singh R, Singh AK, Madhu Tripathi (2012) Effect of an aromatase inhibitor analogue tamoxifen on the gonad and sex differentiation in Nile tilapia Oreochromis niloticus.
(ii) Studies that addressed the association between the third-generation bisphosphonates with aromatase inhibitor in breast cancer treatment,
Masculinization of female golden rabbitfish Siganus guttatus using an aromatase inhibitor treatment during sex differentiation.
Bone mineral density decreased over time in the exemestane group; however, patients on the aromatase inhibitor had no increased risk of fractures.
Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review.
Thus, hormonal agents have been evaluated as potential treatments for advanced stage or recurrent adult granulosa cell tumours.2,6,7 Recently several published reports have indicated the possible use of hormonal therapy in the management of recurrent chemoresistent or progressive non-responding granulose-theca cell tumours, including medroxyprogesterone acetate, GnRH agonists, and megestrol (Megace).8 Aromatase inhibitor Anastrozole, which inhibit the conversion of androstenedione to estrone, is described recently in the management of GCT patients who previously received surgery and chemotherapy.6,7,9
Arimidex: a potent and selective fourth-generation aromatase inhibitor. Breast Cancer Res Treat 1994;30:103-11.
Exemestane, a different kind of drug called an aromatase inhibitor, lessens the amount of estrogen made in the body.
Not all breast cancer patients are eligible to take tamoxifen or aromatase inhibitors, but for some patients with estrogen-sensitive tumors, doctors are now prescribing both drugs, a five-year course of tamoxifen followed by a five-year course of an aromatase inhibitor.