aromatase inhibitor


Also found in: Dictionary, Thesaurus, Legal, Acronyms, Encyclopedia, Wikipedia.

aromatase inhibitor

n. Abbr. AI
Any of several drugs that affect the levels of steroids in the blood by inhibiting the enzyme aromatase. Aromatase inhibitors are used especially to lower estrogen levels to control the growth or prevent the recurrence of estrogen-sensitive tumors in post-menopausal women with breast cancer.

aromatase inhibitor

Any of a class of drugs that block the synthesis of estrogen in the body. A number of these agents have been developed to treat breast cancer, which is often a hormone-responsive malignancy.
See also: inhibitor
References in periodicals archive ?
An aromatase inhibitor or high water temperature induce oocyte apoptosis and depletion of P450 aromatase activity in the gonads of genetic female zebrash during sex-reversal.
Sun L, Zha J, Spear PA, Wang Z (2007a) Toxicity of the aromatase inhibitor letrozole to Japanese medaka (Oryzias latipes) eggs, larvae and breeding adults.
Masculinization of female golden rabbitfish Siganus guttatus using an aromatase inhibitor treatment during sex differentiation.
These researchers noticed that some patients on aromatase inhibitors had less pain when they took high doses of vitamin D.
4 Several authors have recommended aromatase inhibitors as a treatment strategy for recurrent and refractory disease.
Such reductions were subsequently confirmed in trials testing the other two potent aromatase inhibitors, letrozole and exemestane.
The results suggest that taking an aromatase inhibitor such as exemestane reduces a woman's risk of developing invasive breast cancer by 65 percent, says study coauthor Paul Goss, a physician at Harvard Medical School in Boston.
Aromatase inhibitors reduce the amount of estrogen in the body by blocking the enzyme aromatase, which turns androgen into estrogen.
Biochemical and cell culture studies have demonstrated that conjugated linoleic acid (CLA) is the aromatase inhibitor in mushrooms.
In this study, when DHEA-sulfate was administered with an aromatase inhibitor, the cancer cells were induced to commit suicide.
Special emphasis has been placed on the mechanism of action of the aromatase inhibitor compared to that of clomiphene citrate, since the aromatase inhibitor lacks an anti-oestrogenic effect on the endometrium and cervical mucus.
The new agent, which is an aromatase inhibitor, is indicated for the treatment of postmenopausal breast cancer.