aromatase


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aromatase

 [ah-ro´mah-tās]
an enzyme activity occurring in the endoplasmic reticulum and catalyzing the conversion of testosterone to the aromatic compound estradiol.

aromatase

/aro·ma·tase/ (ah-ro´mah-tās) an enzyme activity in the endoplasmic reticulum that catalyzes the conversion of testosterone to the aromatic compound estradiol.

aromatase

(ə-rō′mə-tāz′, -tāz′)
n.
A key enzyme in the biosynthesis of steroids, especially in the conversion of androgens to estrogens.

aromatase

[ah-ro′mah-tās]
an enzyme activity occurring in the endoplasmic reticulum and catalyzing the conversion of testosterone to the aromatic compound estradiol.

CYP19A1

A gene on chromosome 15q21.1 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP19A1 localises to the endoplasmic reticulum and catalyses the last steps of oestrogen biosynthesis—three successive hydroxylations of the A ring of androgens.

Molecular pathology
CYP19A1 mutations can up- or downregulate aromatase activity.
References in periodicals archive ?
Cytochrome P450 aromatase 1a)###3'-ACTTACTGCGGTGTATTGT-5'
Chemicals acting on aromatase mRNA synthesis, degradation, or translation, or on aromatase itself, should give positive results in this assay (Chen et al.
These studies demonstrated the importance of research on genetic characterization for the aromatase gene in distinct populations.
Major finding: Women who had been on adjuvant aromatase inhibitor therapy for a median of 5.
carpio significantly accounted for suppressed E2 level which consequently elevated T level suggesting that aromatase based sex determination occurs in Nile tilapia and common carp.
Unfortunately, approximately one-third of all men develop aromatase overactivity, a few as early as their late 30s, the majority in their 40s and 50s, and a lesser number at older ages.
Aromatase is responsible for the final step in estrogen biosynthesis, catalyzing the aromatization of androstenedione and testosterone into estrone and estradiol, respectively (Haynes et al.
But I never addressed the joint and muscle pain that often accompanies the use of aromatase inhibitors.
When oral contraceptives (OCs) or gonadotropin-releasing hormone (GnRH) agonists fail to relieve pain, 1 prescribe a continuous OC with an aromatase inhibitor--typically letrozole (Femara, Novartis) at a dosage of 2.
We present a case of recurrent and treatment refractory GCT in a postmenopausal patient, managed by aromatase inhibitor Anastrozole with reasonable efficacy.
Aromatase inhibitors block the enzyme aromatase, which is responsible for conversion of the adrenal derived precursor, androstenedione, to estrogen in tissues such as fat, muscle, and in the breast in postmenopausal women.
CHICAGO - The bone loss associated with aromatase inhibitors was significantly slowed with increasing supplements of vitamin D in a prospective cohort study of 156 postmenopausal women.