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an enzyme activity occurring in the endoplasmic reticulum and catalyzing the conversion of testosterone to the aromatic compound estradiol.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
A key enzyme in the biosynthesis of steroids, especially in the conversion of androgens to estrogens.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
CYP19A1A gene on chromosome 15q21.1 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP19A1 localises to the endoplasmic reticulum and catalyses the last steps of oestrogen biosynthesis—three successive hydroxylations of the A ring of androgens.
CYP19A1 mutations can up- or downregulate aromatase activity.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.