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aromatase/aro·ma·tase/ (ah-ro´mah-tās) an enzyme activity in the endoplasmic reticulum that catalyzes the conversion of testosterone to the aromatic compound estradiol.
A key enzyme in the biosynthesis of steroids, especially in the conversion of androgens to estrogens.
an enzyme activity occurring in the endoplasmic reticulum and catalyzing the conversion of testosterone to the aromatic compound estradiol.
CYP19A1A gene on chromosome 15q21.1 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP19A1 localises to the endoplasmic reticulum and catalyses the last steps of oestrogen biosynthesis—three successive hydroxylations of the A ring of androgens.
CYP19A1 mutations can up- or downregulate aromatase activity.