carpio significantly accounted for suppressed E2 level which consequently elevated T level suggesting that aromatase
based sex determination occurs in Nile tilapia and common carp.
Hormone-receptor-positive breast cancer in postmenopausal women is treated increasingly with aromatase
inhibitors because of increased efficacy and reduced incidence of endometrial cancer compared with tamoxifen.
It's the ever-increasing insulin signal that activates the aromatase
enzyme, making more and more testosterone turn into estrogen.
In the present study, masculinization of undifferentiated yellow catfish was induced by administration of the aromatase
inhibitor (AI) letrozol (LZ).
Several patients with recurrent disease demonstrated normalisation of their serum inhibin, decrease in tumour size, and an increase in disease-free survival.4 Several authors have recommended aromatase
inhibitors as a treatment strategy for recurrent and refractory disease.1,7
A randomised trial comparing two doses of the new selective aromatase
inhibitor anastrozole (Arimidex) with megestrol acetate in postmenopausal patients with advanced breast cancer.
The findings suggest that vitamin D supplementation at doses higher than the standard of 400-800 IU/day might be useful to minimize bone loss in women starting out on aromatase
inhibitors and who are not eligible for bisphosphonate therapy according to current guidelines.
Lack of complete cross-resistance between different aromatase
inhibitors; a real finding in search for an explanation?
White button mushrooms (Agaricus bisporous) are a potential chemopreventive agent against breast cancer and prostate cancer, as they suppress aromatase
and steroid reductase, and inhibit the proliferation of breast and prostate cancer cells.
Chen began investigating mushrooms because his lab's studies found that ingredients in the mushrooms suppressed the effects of a natural substance in the body called aromatase
. Blocking aromatase
is a key way that physicians reduce circulating estrogen levels among their postmenopausal patients.
For this reason, anti-estrogen drugs such as tamoxifen and aromatase
inhibitors have come to the forefront in the fight against hormone-dependent breast cancer.
ABSTRACT: Cytochrome P450 aromatase
is responsible for the biosynthesis of estrogen.