activated macrophage

(redirected from armed macrophage)
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ac·ti·vat·ed mac·ro·phage

a mature macrophage, in an active metabolic state, that is cytotoxic to tumor/target cells, usually following exposure to certain cytokines.
Synonym(s): armed macrophage

activated macrophage

A mononuclear phagocyte that has been “turned on”—i.e., has enhanced activity by cytokines. Activated macrophages (AMs) are twice the size of resting macrophages and more aggressive (increased lysozymes and surface expression of MHC class-II antigens), and are pivotal in defending a host against microorganisms that grow well within histiocytes/tissue-based macrophages and other cells—e.g., Listeria spp, and Salmonella spp.

activated macrophage

Immunology A mononuclear phagocyte that has been 'turned on'–ie has enhanced activity by cytokines; AMs are bigger–twice the size of resting macrophages and 'badder'–↑ lysozymes and surface expression of MHC class II antigens, and are pivotal in defending against microorganisms that grow well in histiocytes/tissue-based macrophages and other cells–eg, Listeria spp, and Salmonella spp