aristolochic acids


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a·ris·to·loch·ic ac·ids

(ă'ris-tō-lō'kik as'idz),
Aromatic mixtures of nitrophenanthrene derivatives from plants of the genus Aristolochia. Some are components of various Chinese herbal medications, known to cause interstitial renal fibrosis that can progress to end-stage renal disease (ESRD) even after discontinuation of intake. Some are potent carcinogens, employed in animal and bacterial studies. Human urothelial carcinomas can result from their use.
References in periodicals archive ?
While papaverine N-oxide (99) and aristolochic acids (118 and 119) having a common biosynthetic pathway, but, from the standpoint of chemistry, it is a different class of organic compounds.
Studies on the metabolism of aristolochic acids 1 and 11.
Naturally occurring aristolactams, aristolochic acids and dioxoaporphines and their biological activities.
With the outcome of their study, the researchers hope to raise awareness of the risks of aristolochic acids and reduce the global disease burden from this severe condition.
The scientists reviewed worldwide cases of aristolochic acid nephropathy (AAN) - a type of kidney failure caused by the intake of these acids.
Quantitative analysis of aristolochic acids, toxic compounds, contained in some medicinal plants.
The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids.
Presence and absence of aristolochic acids in species of Aristolochiaceae and species of their botanical name-related families Herb Plant part Aristolochiaceae (Madouling Ke [TEXT NOT REPRODUCIBLE IN ASCII]) Aristolochia fangchi Y.
Letter to industry associations regarding safety concerns related to the use of botanical products containing aristolochic acid.
In August 1999, two new cases of interstitial fibrosis, in which the patients had consumed botanical preparations containing aristolochic acid, were reported from the United Kingdom.
In addition, aristolochic acid was detected in several finished products sold as dietary supplements.