aristolochic acid


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aristolochic acid

Pseudomedicine
A carcinogenic substance found in a Chinese traditional herb, Aristolochia fangchi, and in herbal weight-loss products, which has been linked to urothelial cancer and end-stage renal disease.
While the FDA issued a warning to this effect in 2001, aristolochic acid still is found in products sold in the US.

aristolochic acid

C17H11NO7, an acid derived from Aristolochia, a genus of flowering plants, and used as an herbal remedy. It is promoted as an aphrodisiac, a weight loss agent, and an anticonvulsant.
CAS # 313-67-7

CAUTION!

The acid is a known carcinogen, and its use has been associated with and may cause end-stage renal disease and cancers of the urinary tract that may occur many years after usage has stopped.
See also: acid
References in periodicals archive ?
With the outcome of their study, the researchers hope to raise awareness of the risks of aristolochic acids and reduce the global disease burden from this severe condition.
In addition, aristolochic acid was detected in several finished products sold as dietary supplements.
Aristolochic acid nephropathy revisited: A place for innate and adaptive immunity?
Naturally occurring aristolochic acid analogues and their toxicities.
The aristolochic acid is a plant compound contained in herbal remedies used for thousands of years to treat a variety of ailments like arthritis, gout and inflammation.
Closer analysis showed evidence of cancer cells in the pelvic area around the kidneys, and genetic material isolated from the tissue indicated the presence of aristolochic acid.
Even when the agency is able to act, how is it supposed to know which products contain aristolochic acid, and who sells them?
HPLC fingerprint analysis of paeonol, paeoniflorin and aristolochic acid from subtle granular MCR extract was marker in Fig.
Keywords: Aristolochic acid I; Herba Asari; Asarum: Aristolochia; Liquid chromatography--mass spectrometry
Surprisingly, most of the mutants avoided all but one of the bitter compounds - aristolochic acid, a naturally occurring chemical produced by plants to prevent themselves from being eaten by insects.
Washington, Dec 22 (ANI): The consumption of popular Chinese herbal products containing carcinogen aristolochic acid is linked to an increased risk of urinary tract cancer, a new study has found.