EIF2C4

(redirected from argonaute4)

EIF2C4

A gene on chromosome 1p34 that encodes a protein required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC), binding to short RNAs, such as microRNAs or short interfering RNAs, and repressing the translation of mRNAs complementary to them. EIF2C3 lacks endonuclease activity and does not appear to cleave target mRNAs; it interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B.
References in periodicals archive ?
Argonaute1 and Argonaute10 are involved in shoot meristem, Argonaute4 is involved in RNA-directed DNA methylation and silencing of a small class of transposons, and Argonaute7 is involved in the juvenile-adult transition in vegetative development [13, 21].
ARGONAUTE4 control of locus-specific siRNA accumulation end DNA and histone methylation.