complexes carry a population of circulating microRNAs independent of vesicles in human plasma.
McAnulty et al., "Argonaute2
mediates compensatory expansion of the pancreatic [beta] cell," Cell Metabolism, vol.
Cipolletta et al., "ARGONAUTE2
cooperates with SWI/SNF complex to determine nucleosome occupancy at human Transcription Start Sites," Nucleic Acids Research, vol.
Li, "Tools for investigation of the RNA endonuclease activity of mammalian Argonaute2
protein," Analytical Chemistry, vol.
, a link between genetic and biochemical analyses of RNAi," Science, vol.
Kroh et al., "Argonaute2
complexes carry a population of circulating microRNAs independent of vesicles in human plasma," Proceedings of the National Academy of Sciences of the United States of America, vol.
Another study showed that MSC-EVs contained ribonucleoproteins, such as T cell internal antigen-1 (TIA), TIA1-related (TIAR) and AU-rich element binding protein (Hu R), argonaute2
(Ago2), staufen1 (Stau1) and staufen2 (Stau2) proteins, which are implicated in the transport and stability of mRNA .
Sadovsky, "The expression of Argonaute2
and related microRNA biogenesis proteins in normal and hypoxic trophoblasts," Molecular Human Reproduction, vol.
found potentially 90% of miRNAs in the circulation were present in a non-membrane-bound form, and circulating miRNAs cofractionated with Argonaute2
complexes rather than with vesicles .
Most circulating miRNAs are associated with Argonaute2
, which is part of the RISC silencing complex.
Transcription, splicing RNA-directed DNA polymerase and replication (reverse transcriptase) Reverse transcriptase RNA-directed DNA polymerase (reverse transcriptase) DNA-directed RNA polymerase, beta subunit RNA polymerase alpha subunit Argonaute2
(AGO2) Predicted metal-dependent RNase Group II intron reverse transcriptase/maturase Histone H3.3 Retrotransposon protein 3.
Matsushita et al., "Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2
knockdown," Biochemical and Biophysical Research Communications, vol.