EIF2C2

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EIF2C2

A gene on chromosome 8q24 that encodes a protein required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC), binding to short RNAs, such as microRNAs or short interfering RNAs, and represseing the translation of mRNAs complementary to them. EIF2C2 lacks endonuclease activity and does not appear to cleave target mRNAs. It is required for transcriptional gene silencing of promoter regions which are complementary to bound short anti-gene RNA through inhibition of translation, independent of endonuclease activity.
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Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma.
Most circulating miRNAs are associated with Argonaute2, which is part of the RISC silencing complex.
Transcription, splicing RNA-directed DNA polymerase and replication (reverse transcriptase) Reverse transcriptase RNA-directed DNA polymerase (reverse transcriptase) DNA-directed RNA polymerase, beta subunit RNA polymerase alpha subunit Argonaute2 (AGO2) Predicted metal-dependent RNase Group II intron reverse transcriptase/maturase Histone H3.
In a recent study (62), high frequency copy number abnormalities of Dicer1, Argonaute2, and other miRNA-associated genes in breast and ovarian cancers have been found.
The Science paper describes the discovery of the protein, Argonaute2, isolated from cultured Drosophila cells, which is the first component of RNAi-induced silencing complex identified.