EIF2C2

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EIF2C2

A gene on chromosome 8q24 that encodes a protein required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC), binding to short RNAs, such as microRNAs or short interfering RNAs, and represseing the translation of mRNAs complementary to them. EIF2C2 lacks endonuclease activity and does not appear to cleave target mRNAs. It is required for transcriptional gene silencing of promoter regions which are complementary to bound short anti-gene RNA through inhibition of translation, independent of endonuclease activity.
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Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma.
McAnulty et al., "Argonaute2 mediates compensatory expansion of the pancreatic [beta] cell," Cell Metabolism, vol.
Cipolletta et al., "ARGONAUTE2 cooperates with SWI/SNF complex to determine nucleosome occupancy at human Transcription Start Sites," Nucleic Acids Research, vol.
Li, "Tools for investigation of the RNA endonuclease activity of mammalian Argonaute2 protein," Analytical Chemistry, vol.
Hannon, "Argonaute2, a link between genetic and biochemical analyses of RNAi," Science, vol.
Kroh et al., "Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma," Proceedings of the National Academy of Sciences of the United States of America, vol.
Another study showed that MSC-EVs contained ribonucleoproteins, such as T cell internal antigen-1 (TIA), TIA1-related (TIAR) and AU-rich element binding protein (Hu R), argonaute2 (Ago2), staufen1 (Stau1) and staufen2 (Stau2) proteins, which are implicated in the transport and stability of mRNA [43].
Sadovsky, "The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblasts," Molecular Human Reproduction, vol.
found potentially 90% of miRNAs in the circulation were present in a non-membrane-bound form, and circulating miRNAs cofractionated with Argonaute2 complexes rather than with vesicles [27].
Most circulating miRNAs are associated with Argonaute2, which is part of the RISC silencing complex.
Transcription, splicing RNA-directed DNA polymerase and replication (reverse transcriptase) Reverse transcriptase RNA-directed DNA polymerase (reverse transcriptase) DNA-directed RNA polymerase, beta subunit RNA polymerase alpha subunit Argonaute2 (AGO2) Predicted metal-dependent RNase Group II intron reverse transcriptase/maturase Histone H3.3 Retrotransposon protein 3.
Matsushita et al., "Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown," Biochemical and Biophysical Research Communications, vol.